2009
Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis
Song H, Zhang B, Watson M, Humphrey P, Lim H, Milbrandt J. Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene 2009, 28: 3307-3319. PMID: 19597465, PMCID: PMC2746257, DOI: 10.1038/onc.2009.181.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtrophyClusterinDisease Models, AnimalDisease ProgressionDown-RegulationGene DeletionGene Expression ProfilingGene Expression Regulation, NeoplasticHomeodomain ProteinsHumansLasersMaleMiceMicrodissectionOxidoreductases Acting on Sulfur Group DonorsProstateProstatic NeoplasmsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mycPTEN PhosphohydrolaseSignal TransductionThioredoxinsTranscription FactorsTranscription, GeneticTranscriptional ActivationConceptsNKX3.1 lossMolecular consequencesGene expressionProstate tumorigenesisPTEN-AKTCancer initiationProstate cancer initiationCohort of genesNumber of genesC-Myc signaling pathwayDownstream target genesHuman prostate tumorigenesisLoss of NKX3.1NKX3.1 expressionTumor suppressor geneGene expression data setsExpression data setsQuiescin Q6Transcriptional regulatorsIndependent lossesExpression of NKX3.1Laser capture microdissectionTarget genesCancer gene expression data setsSignaling pathways
1998
Immunohistologic Evaluation of Putatively Mutant p53 Protein in Cutaneous Melanocytic Neoplasms
Kaleem Z, Lind A, Humphrey P, Swanson P, Sueper R, Ritter J, Wick M. Immunohistologic Evaluation of Putatively Mutant p53 Protein in Cutaneous Melanocytic Neoplasms. International Journal Of Surgical Pathology 1998, 6: 73-79. DOI: 10.1177/106689699800600203.Peer-Reviewed Original ResearchImmunohistologic evaluationMutant p53 proteinNuclear labelingMelanocytic neoplasmsLentigo maligna melanomaP53 proteinHigh-power microscopic fieldCutaneous melanocytic neoplasmsBenign melanocytic neoplasmsP53 tumor suppressor geneMaligna melanomaNodular melanomaMalignant melanomaLatter lesionsMelanocytic proliferationMelanomaHuman malignanciesMelanocytic lesionsTumor suppressor geneSpitz neviCommon neviGenetic alterationsNeviMp53Neoplasms