1999
Genetic Analysis of Prostatic Atypical Adenomatous Hyperplasia (Adenosis)
Doll J, Zhu X, Furman J, Kaleem Z, Torres C, Humphrey P, Donis-Keller H. Genetic Analysis of Prostatic Atypical Adenomatous Hyperplasia (Adenosis). American Journal Of Pathology 1999, 155: 967-971. PMID: 10487854, PMCID: PMC1866890, DOI: 10.1016/s0002-9440(10)65196-6.Peer-Reviewed Original ResearchMeSH KeywordsAllelesChromosomes, HumanHumansLoss of HeterozygosityMaleMicrosatellite RepeatsPrecancerous ConditionsProstatic HyperplasiaProstatic Neoplasms
1998
Pseudohyperplastic Prostatic Adenocarcinoma
Humphrey P, Kaleem Z, Swanson P, Vollmer R. Pseudohyperplastic Prostatic Adenocarcinoma. The American Journal Of Surgical Pathology 1998, 22: 1239-1246. PMID: 9777986, DOI: 10.1097/00000478-199810000-00009.Peer-Reviewed Original ResearchConceptsCases of adenocarcinomaProstatic adenocarcinomaHyperplastic featuresNeedle biopsyProstate carcinoma growthUsual epithelial hyperplasiaProstatic needle biopsyLow Gleason scoreLow-grade carcinomaRadical prostatectomy specimensRadical prostatectomy tissueGleason pattern 2Cystic dilatationPathologic stagePrognostic implicationsTumor sizeGleason scoreHistologic gradePapillary infoldingsRadical prostatectomyUsual hyperplasiaHistologic variantsPrognostic informationProstatic carcinomaCarcinomatous fociProstatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy Specimens
Kaleem Z, Swanson P, Vollmer R, Humphrey P. Prostatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy Specimens. American Journal Of Clinical Pathology 1998, 109: 695-703. PMID: 9620026, DOI: 10.1093/ajcp/109.6.695.Peer-Reviewed Original ResearchConceptsAtrophic featuresProstatic adenocarcinomaRadical prostatectomy specimensProstatic carcinomaAtrophic carcinomaProliferation indexProstatectomy specimensCarcinoma volumeUsual prostatic adenocarcinomaInfiltrative growth patternMean proliferation indexKi-67 immunolabelingBiotin nick end labelingRadical prostatectomy casesProstatic adenocarcinoma casesGleason grade 3Nick end labelingAtrophic patternUntreated patientsAtrophic changesPathologic stagePrognostic implicationsGlandular atrophyHistologic gradeAdenocarcinoma cases
1997
The Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy
Henneberry J, Kahane H, Humphrey P, Keetch D, Epstein J. The Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy. The American Journal Of Surgical Pathology 1997, 21: 725-728. PMID: 9199652, DOI: 10.1097/00000478-199706000-00014.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaRepeat biopsyNeedle biopsyBenign glandsIntraluminal crystalloidsIntraepithelial neoplasiaBiopsy resultsSerum prostatic specific antigen (PSA) levelsSerum prostate-specific antigen valuesProstatic-specific antigen levelProstate-specific antigen valuesConsecutive needle biopsiesSpecific antigen levelsBenign prostatic glandsIncidence of cancerJohns Hopkins HospitalProstate biopsy resultsDianon SystemsConcurrent carcinomaSubsequent biopsyFirst biopsyAntigen levelsCystoprostatectomy specimensAntigen values
1995
Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels
Nadler R, Humphrey P, Smith D, Catalona W, Ratliff T. Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels. Journal Of Urology 1995, 154: 407-413. DOI: 10.1016/s0022-5347(01)67064-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overHumansMaleMiddle AgedMultivariate AnalysisProstate-Specific AntigenProstatic HyperplasiaProstatitisUltrasonographyConceptsHigh PSA groupMultiple negative biopsiesSerum PSA concentrationNegative biopsyRectal examinationPSA groupElevated serum prostate-specific antigen concentrationSerum prostate-specific antigen levelSerum prostate-specific antigen (PSA) concentrationElevated serum prostate-specific antigen (PSA) levelPSA concentrationProstate-specific antigen levelProstate-specific antigen concentrationSubclinical prostatic inflammationSuspicious rectal examinationDetectable prostate cancerSpecific antigen levelsDigital rectal examinationSpecific antigen concentrationBenign prostatic hyperplasiaEffects of inflammationProstatic inflammationPSA elevationProstate volumeAntigen levelsEffect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels
Nadler R, Humphrey P, Smith D, Catalona W, Ratliff T. Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels. Journal Of Urology 1995, 154: 407-413.. PMID: 7541857, DOI: 10.1097/00005392-199508000-00023.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overHumansMaleMiddle AgedMultivariate AnalysisProstate-Specific AntigenProstatic HyperplasiaProstatitisUltrasonographyConceptsHigh PSA groupMultiple negative biopsiesSerum PSA concentrationNegative biopsyProstate volumeRectal examinationPSA groupElevated serum prostate-specific antigen concentrationSerum prostate-specific antigen levelSerum prostate-specific antigen (PSA) concentrationElevated serum prostate-specific antigen (PSA) levelPSA concentrationProstate-specific antigen levelProstate-specific antigen concentrationSubclinical prostatic inflammationSuspicious rectal examinationDetectable prostate cancerSpecific antigen levelsDigital rectal examinationSpecific antigen concentrationBenign prostatic hyperplasiaEffects of inflammationProstatic inflammationPSA elevationAntigen levels
1993
Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma
Ibrahim S, Lightner V, Ventimiglia J, Ibrahim G, Walther P, Bigner D, Humphrey P. Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. Human Pathology 1993, 24: 982-989. PMID: 7504654, DOI: 10.1016/0046-8177(93)90112-t.Peer-Reviewed Original ResearchConceptsWestern blot analysisIntraepithelial neoplasiaCarcinoma cell linesProstatic hyperplasiaProstatic tissueBlot analysisAdult prostatic tissuesMetastatic prostatic carcinomaGrade of adenocarcinomaHuman prostatic carcinoma cell linesBone marrow samplesProstatic carcinoma cell linesHuman prostate tissueCell linesExpression of tenascinConnective tissue frameworkLymph nodesHistologic gradeProstatic carcinomaStromal alterationsTenascin immunoreactivityMarrow samplesStrong immunoreactivityStromal immunoreactivityProstate tissueDifferential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic Tissues
Ibrahim G, Kerns B, MacDonald J, Ibrahim S, Kinney R, Humphrey P, Robertson C. Differential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic Tissues. Journal Of Urology 1993, 149: 170-173. PMID: 7678041, DOI: 10.1016/s0022-5347(17)36032-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedDiagnosis, DifferentialErbB ReceptorsHumansImmunohistochemistryMaleMiddle AgedProstatic HyperplasiaProstatic NeoplasmsConceptsBenign prostatic hyperplasiaEGFR immunoreactivityBasal cell layerLuminal cellsBasal cellsBPH tissueFactor receptorProstatic specific antigenMalignant prostatic tissueAreas of dysplasiaCell layerRadical prostatectomy specimensCap tissueEpidermal growth factor receptorGrowth factor receptorEGFR contentProstatic hyperplasiaImmunohistochemical examinationProstatic carcinomaProstatic specimensProstatectomy specimensProstatic tissue