Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells.
Day M, Zhao X, Wu S, Swanson P, Humphrey P. Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells. Molecular Cancer Research 1994, 5: 735-41. PMID: 7947388.Peer-Reviewed Original ResearchMeSH KeywordsAlkaloidsAndrogensApoptosisCarcinomaDNA DamageDNA-Binding ProteinsDNA, NeoplasmEarly Growth Response Protein 1Enzyme InductionGene Expression Regulation, NeoplasticHumansImmediate-Early ProteinsMaleNeoplasms, Hormone-DependentProstatic NeoplasmsProtein KinasesProto-Oncogene Proteins c-fosStaurosporineTetradecanoylphorbol AcetateTranscription FactorsTranscriptional ActivationTumor Cells, CulturedConceptsTranscription factor NGFIPhorbol ester-induced apoptosisC-fos gene activationEarly transcriptional regulationKinase signal transductionC-fosProtein kinase activatorsProstate cellsTranscriptional regulationGene activationSignal transductionProtein kinaseInduction of deathKinase activatorLNCaP cellsProstate cancer cellsProstate linesApoptotic bodiesCell deathDNA ladderTransient activationTransient inductionIntracellular pathwaysTPA-induced expressionNGFI