Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells
Chen R, Alvero AB, Silasi DA, Kelly MG, Fest S, Visintin I, Leiser A, Schwartz PE, Rutherford T, Mor G. Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells. Oncogene 2008, 27: 4712-4723. PMID: 18408758, PMCID: PMC3041589, DOI: 10.1038/onc.2008.112.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceFemaleGene Expression Regulation, NeoplasticHumansI-kappa B KinaseMicroRNAsModels, BiologicalMolecular Sequence DataNF-kappa BOvarian NeoplasmsSequence Homology, Nucleic AcidTransfectionTumor Cells, CulturedConceptsOvarian cancer cellsEOC cellsTumor samplesNuclear factor-κB activationCancer cellsOvarian cancer ascitesChemoresistant ovarian cancerNF-κB pathwayNF-κB activityPatient tumor samplesIKKβ pathwayTLR-MyD88Chronic inflammationEffective therapyCancer ascitesOvarian cancerInflammatory microenvironmentIKKβ expressionSolid tumorsTumor progressionCancer progressionIκB kinaseAbnormal formsMicroRNA hsaTissue repair