2017
The MVMp P4 promoter is a host cell-type range determinant in vivo
Meir C, Mincberg M, Rostovsky I, Tal S, Vollmers EM, Levi A, Tattersall P, Davis C. The MVMp P4 promoter is a host cell-type range determinant in vivo. Virology 2017, 506: 141-151. PMID: 28391161, DOI: 10.1016/j.virol.2017.03.012.Peer-Reviewed Original Research
2013
Parvoviral Left-End Hairpin Ears Are Essential during Infection for Establishing a Functional Intranuclear Transcription Template and for Efficient Progeny Genome Encapsidation
Li L, Cotmore SF, Tattersall P. Parvoviral Left-End Hairpin Ears Are Essential during Infection for Establishing a Functional Intranuclear Transcription Template and for Efficient Progeny Genome Encapsidation. Journal Of Virology 2013, 87: 10501-10514. PMID: 23903839, PMCID: PMC3807388, DOI: 10.1128/jvi.01393-13.Peer-Reviewed Original ResearchConceptsDNA replicationA9 cellsC-terminal transactivation domainCapsid gene expressionProtein expressionWild-type virionsProgeny virion productionP38 promoterTransactivation domainTranscription complexInfectious plasmid cloneGenome encapsidationGenome packagingAbsence of progenyGene expressionPlasmid clonesTranscription templateMutant virionsNonstructural proteinsReplacement vectorViral transcriptionViral transcriptsSuch complementationVirion stabilityDuplex DNAParvovirus evades interferon-dependent viral control in primary mouse embryonic fibroblasts
Mattei LM, Cotmore SF, Tattersall P, Iwasaki A. Parvovirus evades interferon-dependent viral control in primary mouse embryonic fibroblasts. Virology 2013, 442: 20-27. PMID: 23676303, PMCID: PMC3767977, DOI: 10.1016/j.virol.2013.03.020.Peer-Reviewed Original ResearchConceptsType I IFNsI IFNsI interferonIFN responseAntiviral immune mechanismsType I interferonInnate defense mechanismsMouse embryonic fibroblastsMVMp infectionViral controlImmune mechanismsInnate sensingAntiviral programViral replicationViral sensorsMurine parvovirusPoly (I:C) stimulationVirusEmbryonic fibroblastsType IMiceDefense mechanismsMinute virusMVMpPrimary mouse embryonic fibroblasts
2011
Mutations at the Base of the Icosahedral Five-Fold Cylinders of Minute Virus of Mice Induce 3′-to-5′ Genome Uncoating and Critically Impair Entry Functions
Cotmore SF, Tattersall P. Mutations at the Base of the Icosahedral Five-Fold Cylinders of Minute Virus of Mice Induce 3′-to-5′ Genome Uncoating and Critically Impair Entry Functions. Journal Of Virology 2011, 86: 69-80. PMID: 22013064, PMCID: PMC3255873, DOI: 10.1128/jvi.06119-11.Peer-Reviewed Original ResearchConceptsSubgenomic DNAWild typeAnalysis of progenyMinute virusVP2 N-terminusDNA genomeAccumulation of virionsUncoating reactionGenome releaseImpaired mutantsEndosomal compartmentsEntry defectN-terminusVirion assemblyMutantsProtein capsidGenome uncoatingCation depletionBilayer penetrationCell entryDNAGenomeVP1 domainTerminusProteolysis
1992
Two amino acid substitutions within the capsid are coordinately required for acquisition of fibrotropism by the lymphotropic strain of minute virus of mice
Ball-Goodrich L, Tattersall P. Two amino acid substitutions within the capsid are coordinately required for acquisition of fibrotropism by the lymphotropic strain of minute virus of mice. Journal Of Virology 1992, 66: 3415-3423. PMID: 1316457, PMCID: PMC241122, DOI: 10.1128/jvi.66.6.3415-3423.1992.Peer-Reviewed Original ResearchConceptsRestrictive infectionDouble mutant virusLymphotropic strainViral life cycleMinute virusInfectionImmunosuppressive strainFibroblast infectionVirusParvovirus minute virusMutant virusA9 fibroblastsCodon 317MiceCodon 321Amino acid substitutionsFibroblastsSame cellsCapsid geneCellsGene expressionAcid substitutionsSynergistic interactionNucleotide changesA9 cellsThe pathogenesis of infection with minute virus of mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2
Brownstein D, Smith A, Johnson E, Pintel D, Naeger L, Tattersall P. The pathogenesis of infection with minute virus of mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2. Journal Of Virology 1992, 66: 3118-3124. PMID: 1373202, PMCID: PMC241074, DOI: 10.1128/jvi.66.5.3118-3124.1992.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCapsidDNA, ViralEpitopesGenetic VariationImmunohistochemistryMiceMice, Inbred C3HMinute virus of miceMutagenesisNucleic Acid HybridizationParvoviridae InfectionsStructure-Activity RelationshipTissue DistributionViral Core ProteinsViral Nonstructural ProteinsVirulenceConceptsPathogenesis of infectionAsymptomatic infectionMultiple organsViral capsid antigenMesenteric lymph nodesSmooth muscle cellsSame target cellsMVMi infectionLymph nodesCapsid antigenMVMp infectionLethal infectionC3H/Lymphoid cellsTarget organsSimilar dosesAllotropic determinantMinute virusInfectious virusVirus titrationInfectionMuscle cellsMiceTitersTarget cells
1991
Pathogenesis of infection with a virulent allotropic variant of minute virus of mice and regulation by host genotype.
Brownstein D, Smith A, Jacoby R, Johnson E, Hansen G, Tattersall P. Pathogenesis of infection with a virulent allotropic variant of minute virus of mice and regulation by host genotype. Laboratory Investigation 1991, 65: 357-64. PMID: 1653878.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGenetic VariationGenotypeImmunohistochemistryKidneyLiverMiceMice, Inbred StrainsMinute virus of miceNucleic Acid HybridizationParvoviridae InfectionsVirulenceConceptsViral capsid antigenH miceInfectious virus titersB6 miceMVMi infectionCapsid antigenLethal infectionVirus titersPathogenesis of infectionBALB/cStrains of miceMinute virusAccelerated involutionSitu hybridizationC57BL/6 miceAsymptomatic infectionIntestinal hemorrhageNeonatal micePapillary hemorrhageDBA/2 miceC3H miceTarget organsVirus titrationVirus replicationGenetic susceptibility
1987
Human Parvovirus B19 Infection During Pregnancy
Woernle C, Anderson L, Tattersall P, Davison J. Human Parvovirus B19 Infection During Pregnancy. The Journal Of Infectious Diseases 1987, 156: 17-20. PMID: 3036955, DOI: 10.1093/infdis/156.1.17.Peer-Reviewed Original ResearchConceptsIgM-positive womenB19 infectionFetal deathFifth diseaseIgM antibodies to B19Outbreak of fifth diseaseAssociated with fetal deathHuman parvovirus B19 infectionLow riskHigh riskAntibodies to B19Identified pregnant womenParvovirus B19 infectionHuman parvovirus B19No adverse effectsHydropic fetusesFetal infectionB19 DNACord serumParvovirus B19Pregnant womenPrenatal careHigh risk of exposureInfectionB19
1986
Identification of the major structural and nonstructural proteins encoded by human parvovirus B19 and mapping of their genes by procaryotic expression of isolated genomic fragments
Cotmore S, McKie V, Anderson L, Astell C, Tattersall P. Identification of the major structural and nonstructural proteins encoded by human parvovirus B19 and mapping of their genes by procaryotic expression of isolated genomic fragments. Journal Of Virology 1986, 60: 548-557. PMID: 3021988, PMCID: PMC288924, DOI: 10.1128/jvi.60.2.548-557.1986.Peer-Reviewed Original ResearchConceptsProtein sequencesViral capsid polypeptidesCapsid polypeptidesSucrose velocity gradientsB19 genomeBacterial plasmid vectorRestriction endonuclease fragmentsGenomic fragmentProtein speciesApparent molecular weightNonstructural polypeptidesExpression constructsSimilar proteinsBAL-31GenomeExpression vectorNonstructural proteinsEndonuclease fragmentsPlasmid vectorViral genomeViral polypeptidesPolypeptide fragmentsProcaryotic expressionPolypeptideProteinDetection of antibodies and antigens of human parvovirus B19 by enzyme-linked immunosorbent assay
Anderson L, Tsou C, Parker R, Chorba T, Wulff H, Tattersall P, Mortimer P. Detection of antibodies and antigens of human parvovirus B19 by enzyme-linked immunosorbent assay. Journal Of Clinical Microbiology 1986, 24: 522-526. PMID: 3021807, PMCID: PMC268963, DOI: 10.1128/jcm.24.4.522-526.1986.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayB19 IgG antibodiesYears of ageHuman parvovirus B19Aplastic crisisAntibody detection enzyme-linked immunosorbent assayB19 antibodiesIgG antibodiesParvovirus B19IgM enzyme-linked immunosorbent assayDays of onsetAntibody enzyme-linked immunosorbent assayAcute-phase seraDetection of antibodiesEnzyme-linked immunosorbentDNA hybridizationElectron microscopyB19 infectionB19 IgMFifth diseaseB19 DNAImmunoglobulin MSerum specimensLow titersHigh titersThe Role of Parvovirus B19 in Aplastic Crisis and Erythema Infectiosum (Fifth Disease)
Chorba T, Coccia P, Holman R, Tattersall P, Anderson L, Sudman J, Young N, Kurczynski E, Saarinen U, Moir R, Lawrence D, Jason J, Evatt B. The Role of Parvovirus B19 in Aplastic Crisis and Erythema Infectiosum (Fifth Disease). The Journal Of Infectious Diseases 1986, 154: 383-393. PMID: 3016109, DOI: 10.1093/infdis/154.3.383.Peer-Reviewed Original ResearchConceptsErythema infectiosumAplastic crisisParvovirus B19B19-specific IgMSecondary attack rateSimultaneous outbreaksThroat garglesB19 infectionClinical entityRecent infectionAsymptomatic infectionSusceptible contactsPatientsInfectionB19Attack rateSerumComparison groupIgMHousehold membersOutbreakGargleEpidemiologyUrineHuman parvovirus B19-induced epidemic acute red cell aplasia in patients with hereditary hemolytic anemia.
Saarinen U, Chorba T, Tattersall P, Young N, Anderson L, Palmer E, Coccia P. Human parvovirus B19-induced epidemic acute red cell aplasia in patients with hereditary hemolytic anemia. Blood 1986, 67: 1411-7. PMID: 3008891, DOI: 10.1182/blood.v67.5.1411.bloodjournal6751411.Peer-Reviewed Original ResearchConceptsRed cell aplasiaAcute-phase seraHuman parvovirus B19Cell aplasiaHemolytic anemiaHereditary hemolytic anemiaParvovirus B19B19-specific IgMHemoglobin SC diseaseDays of presentationB19-specific IgGParvovirus B19 DNASickle cell anemiaHuman parvovirus B19 DNAErythroid colony formationAbdominal symptomsSevere reticulocytopeniaAcute onsetAdditional patientsProdromal symptomsSC diseaseB19 DNAViremic seraPatientsCell anemia