2021
Exosomes provide unappreciated carrier effects that assist transfers of their miRNAs to targeted cells; I. They are ‘The Elephant in the Room’
Askenase PW. Exosomes provide unappreciated carrier effects that assist transfers of their miRNAs to targeted cells; I. They are ‘The Elephant in the Room’. RNA Biology 2021, 18: 2038-2053. PMID: 33944671, PMCID: PMC8582996, DOI: 10.1080/15476286.2021.1885189.Peer-Reviewed Original ResearchConceptsExtracellular vesiclesAcceptor cellsOuter membrane vesiclesMiRNA transferMolecular chemical changesNano-extracellular vesiclesCargo moleculesExosome transferMembrane vesiclesMiRNAsGenetic expressionDNA expressionExosomesVesiclesCell functionIntracellular effectsFunctional effectsFunctional alterationsMolecular transferCellsPhysiologic processesLight chainExpressionMitochondriaBiology
2011
Participation of Inkt Cells in the Early and Late Components of Tc1‐Mediated DNFB Contact Sensitivity: Cooperative Role of γδ‐T Cells
Askenase PW, Majewska‐Szczepanik M, Kerfoot S, Szczepanik M. Participation of Inkt Cells in the Early and Late Components of Tc1‐Mediated DNFB Contact Sensitivity: Cooperative Role of γδ‐T Cells. Scandinavian Journal Of Immunology 2011, 73: 465-477. PMID: 21272050, DOI: 10.1111/j.1365-3083.2011.02522.x.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsDermatitis, ContactDinitrofluorobenzeneFemaleFlow CytometryImmunizationImmunophenotypingInterferon-gammaMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred CBAMice, KnockoutNatural Killer T-CellsReceptors, Antigen, T-Cell, alpha-betaSpecific Pathogen-Free OrganismsT-Lymphocytes, Cytotoxic
2008
Identification of Initiator B Cells, a Novel Subset of Activation-Induced Deaminase-Dependent B-1-Like Cells That Mediate Initiation of Contact Sensitivity
Kerfoot SM, Szczepanik M, Tung JW, Askenase PW. Identification of Initiator B Cells, a Novel Subset of Activation-Induced Deaminase-Dependent B-1-Like Cells That Mediate Initiation of Contact Sensitivity. The Journal Of Immunology 2008, 181: 1717-1727. PMID: 18641308, DOI: 10.4049/jimmunol.181.3.1717.Peer-Reviewed Original ResearchConceptsContact sensitivityB cellsCS initiationInflammatory responseT cell-mediated inflammationProinflammatory T cellsCell-mediated inflammationAdoptive transfer experimentsDelayed-type hypersensitivityAg-specific IgMReceptor gene mutationsSensitized miceVascular activationDeficient recipientsT cellsNovel subsetSomatic hypermutationNovel subpopulationGene mutationsIgMMiceActivation-Induced DeaminaseWT cellsCellsChain gene
1977
Studies on the role of the thymus and T cells in the in vivo suppression of delayed hypersensitivity (desensitization): radiosensitivity of the mechanism inducing nonspecific anergy.
Thestrup-Pedersen K, Dwyer J, Askenase P. Studies on the role of the thymus and T cells in the in vivo suppression of delayed hypersensitivity (desensitization): radiosensitivity of the mechanism inducing nonspecific anergy. The Journal Of Immunology 1977, 118: 1665-71. PMID: 300755, DOI: 10.4049/jimmunol.118.5.1665.Peer-Reviewed Original ResearchConceptsT cellsDelayed hypersensitivitySuppression of delayed hypersensitivityDoses of whole-body irradiationNonspecific desensitizationMature T cellsWhole-body irradiationMono-nuclear cellsIn vivo suppressionThymic weightImmunoregulatory mechanismsPeripheral bloodRadiosensitive cellsAssociated with 1AnergySmall dosesDecreased responseGuinea pigsSkin sitesDesensitizationAntigenDesensitized stateConcanavalin AHypersensitivityCells