2021
Antibodies Enhance the Suppressive Activity of Extracellular Vesicles in Mouse Delayed-Type Hypersensitivity
Nazimek K, Bustos-Morán E, Blas-Rus N, Nowak B, Totoń-Żurańska J, Seweryn MT, Wołkow P, Woźnicka O, Szatanek R, Siedlar M, Askenase PW, Sánchez-Madrid F, Bryniarski K. Antibodies Enhance the Suppressive Activity of Extracellular Vesicles in Mouse Delayed-Type Hypersensitivity. Pharmaceuticals 2021, 14: 734. PMID: 34451831, PMCID: PMC8398949, DOI: 10.3390/ph14080734.Peer-Reviewed Original ResearchDelayed-type hypersensitivityMice delayed-type hypersensitivityAntigen-specific antibodiesEffector T cellsT cellsSuppressive activityExtracellular vesiclesAntigen-presenting macrophagesMHC class IIGreat therapeutic potentialMouse modelSuppressive actionCurrent studyMiRNA-150Therapeutic potentialClass IIFlow cytometryExact mechanismAntibodiesParental cellsTherapeutic usageHypersensitivityMacrophagesIntercellular communicationSpecific binding
1977
Studies on the role of the thymus and T cells in the in vivo suppression of delayed hypersensitivity (desensitization): radiosensitivity of the mechanism inducing nonspecific anergy.
Thestrup-Pedersen K, Dwyer J, Askenase P. Studies on the role of the thymus and T cells in the in vivo suppression of delayed hypersensitivity (desensitization): radiosensitivity of the mechanism inducing nonspecific anergy. The Journal Of Immunology 1977, 118: 1665-71. PMID: 300755, DOI: 10.4049/jimmunol.118.5.1665.Peer-Reviewed Original ResearchConceptsT cellsDelayed hypersensitivitySuppression of delayed hypersensitivityDoses of whole-body irradiationNonspecific desensitizationMature T cellsWhole-body irradiationMono-nuclear cellsIn vivo suppressionThymic weightImmunoregulatory mechanismsPeripheral bloodRadiosensitive cellsAssociated with 1AnergySmall dosesDecreased responseGuinea pigsSkin sitesDesensitizationAntigenDesensitized stateConcanavalin AHypersensitivityCells
1976
Antibody-Mediated Basophil Accumulations in Cutaneous Hypersensitivity Reactions of Guinea Pigs
Askenase P, Haynes J, Hayden B. Antibody-Mediated Basophil Accumulations in Cutaneous Hypersensitivity Reactions of Guinea Pigs. The Journal Of Immunology 1976, 117: 1722-1730. DOI: 10.4049/jimmunol.117.5_part_1.1722.Peer-Reviewed Original ResearchCutaneous basophil hypersensitivityIncomplete Freund's adjuvantCutaneous hypersensitivity reactionsGuinea pigsDelayed hypersensitivityBasophil accumulationCutaneous basophil hypersensitivity reactionProduction of B lymphocytesHypersensitive responseT lymphocytesKeyhole limpet hemocyanin (KLHPigsB lymphocytesFreund's adjuvantIntradermal injectionDonors 1 weekBasophil reactionsHypersensitivity reactionsAntibody production of B lymphocytesSerum antibodiesHypersensitivityImmune serumAntibody productionSerumCutaneous basophil hypersensitivity uncovered in the cell transfer of classical tuberculin hypersensitivity.
Askenase P. Cutaneous basophil hypersensitivity uncovered in the cell transfer of classical tuberculin hypersensitivity. The Journal Of Immunology 1976, 117: 741-7. PMID: 1085308, DOI: 10.4049/jimmunol.117.3.741.Peer-Reviewed Original ResearchConceptsCell transferIncomplete Freund's adjuvantSkin reactionsCutaneous basophil hypersensitivityGuinea pigsRecipients of cellsNylon wool columnsCell transfer recipientsDelayed skin reactionsT cellsSkin testBasophil responseFreund's adjuvantCellular transferTuberculin hypersensitivitySensitization of recipientsWool columnsBasophil infiltrationHumoral factorsBasophil numbersPassive transferHypersensitivityRecipientsBasophilsDelayed reactionsAntibody-mediated basophil accumulations in cutaneous hypersensitivity reactions of guinea pigs.
Askenase P, Haynes J, Hayden B. Antibody-mediated basophil accumulations in cutaneous hypersensitivity reactions of guinea pigs. The Journal Of Immunology 1976, 117: 216-24. PMID: 932424, DOI: 10.4049/jimmunol.117.1.216.Peer-Reviewed Original ResearchConceptsCutaneous basophil hypersensitivityCutaneous hypersensitivity reactionsGuinea pigsDelayed hypersensitivityBasophil accumulationProduction of B lymphocytesCutaneous basophil hypersensitivity reactionT lymphocytesKeyhole limpet hemocyanin (KLHB lymphocytesIntradermal injectionDonors 1 weekHypersensitive responseHypersensitivity reactionsPigsSerum antibodiesAntibody production of B lymphocytesHypersensitivityBasophil reactionsImmune serumAntibody productionSerum