2024
Harnessing Natural Language Processing to Assess Quality of End-of-Life Care for Children With Cancer
Lindsay M, de Oliveira S, Sciacca K, Lindvall C, Ananth P. Harnessing Natural Language Processing to Assess Quality of End-of-Life Care for Children With Cancer. JCO Clinical Cancer Informatics 2024, 8: e2400134. PMID: 39265122, PMCID: PMC11407740, DOI: 10.1200/cci.24.00134.Peer-Reviewed Original ResearchConceptsEnd-of-life carePalliative care consultationGoals of careLocation of deathProportion of decedentsDocumented discussionCare consultationEvidence-based quality measuresMeasure quality of careGold standard manual chart reviewQuality measuresQuality of careEnd of lifeContent of clinical notesLife-sustaining treatmentEnd-of-lifeManual chart reviewCancer decedentsEfficient quality measureCohort of childrenAssess qualityMulti-center researchQuality improvementMeasure qualityCare
2021
Reenvisioning End-of-Life Care Quality Measurement for Adolescents and Young Adults With Cancer—Novel Patient-Centered Indicators and Approaches
Ananth P. Reenvisioning End-of-Life Care Quality Measurement for Adolescents and Young Adults With Cancer—Novel Patient-Centered Indicators and Approaches. JAMA Network Open 2021, 4: e2122323. PMID: 34424309, DOI: 10.1001/jamanetworkopen.2021.22323.Commentaries, Editorials and LettersSociodemographic and hospital‐based predictors of intense end‐of‐life care among children, adolescents, and young adults with hematologic malignancies
Mun S, Wang R, Ma X, Ananth P. Sociodemographic and hospital‐based predictors of intense end‐of‐life care among children, adolescents, and young adults with hematologic malignancies. Cancer 2021, 127: 3817-3824. PMID: 34185881, PMCID: PMC8478813, DOI: 10.1002/cncr.33764.Peer-Reviewed Original ResearchConceptsHematologic malignanciesYoung adultsLife careMultivariable logistic regression modelCancer-directed treatmentPremier Healthcare DatabaseRetrospective cohort studyEmergency department visitsIntensive care unitHigh-intensity endDays of lifeMajority of childrenLogistic regression modelsIntravenous chemotherapyTracheostomy placementCohort studyDepartment visitsCare unitMechanical ventilationHospital characteristicsMultivariable modelCardiopulmonary resuscitationType of insuranceHealthcare databasesMalignancyA Stakeholder-Driven Qualitative Study to Define High Quality End-of-Life Care for Children With Cancer
Ananth P, Mun S, Reffat N, Li R, Sedghi T, Avery M, Snaman J, Gross CP, Ma X, Wolfe J. A Stakeholder-Driven Qualitative Study to Define High Quality End-of-Life Care for Children With Cancer. Journal Of Pain And Symptom Management 2021, 62: 492-502. PMID: 33556497, PMCID: PMC8339188, DOI: 10.1016/j.jpainsymman.2021.01.134.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildHospice CareHumansNeoplasmsPalliative CareQualitative ResearchTerminal CareYoung AdultConceptsHigh-quality endQuality EOLCAdvanced cancerSymptom managementLife careQuality endLocation of deathMulticenter qualitative studyAvoidance of hospitalizationPerson-centered measuresCancer stakeholdersEnd of lifeSupportive careMechanical ventilationParents of childrenEmergency departmentInterdisciplinary careInterdisciplinary healthcare professionalsCardiopulmonary resuscitationHospice careQualitative studyCancerHealthcare professionalsFamily preferencesYoung adults
2020
Patterns of medication use at end of life by pediatric inpatients with cancer
Prozora S, Shabanova V, Ananth P, Pashankar F, Kupfer GM, Massaro SA, Davidoff AJ. Patterns of medication use at end of life by pediatric inpatients with cancer. Pediatric Blood & Cancer 2020, 68: e28837. PMID: 33306281, DOI: 10.1002/pbc.28837.Peer-Reviewed Original ResearchConceptsMedication usePediatric inpatientsVizient Clinical Database/Resource ManagerHematopoietic stem cell transplantLife-sustaining medicationsMedication utilization patternsSymptom management medicationsUse of opioidsStem cell transplantIntensive care unitLength of stayAcademic medical centerResource use dataLast weekWarrants further studyEvidence-based approachVasopressor useEnd of lifeCare unitCell transplantMedication categoriesResuscitate statusRetrospective studyMalignancy typeOdds ratioParent and patient perceptions of medical marijuana in the childhood cancer context
Ananth P, Revette A, Reed‐Weston A, Das P, Wolfe J. Parent and patient perceptions of medical marijuana in the childhood cancer context. Pediatric Blood & Cancer 2020, 68: e28830. PMID: 33258215, DOI: 10.1002/pbc.28830.Peer-Reviewed Original ResearchConceptsParents of childrenInductive coding approachesPsychological effectsGreater side effect profileParents' perceptionsPediatric cancer careMedical marijuanaParticipantsLack of researchParentsMM useRobust clinical trial dataPerceptionSupportive care medicationsCancer-directed therapyFuture research initiativesSide effect profileYoung adult patientsRelief of nauseaComprehensive cancer centerMarijuanaClinical trial dataFramework analysisAYAsQualitative study
2017
Medical marijuana in pediatric oncology: A review of the evidence and implications for practice
Ananth P, Reed‐Weston A, Wolfe J. Medical marijuana in pediatric oncology: A review of the evidence and implications for practice. Pediatric Blood & Cancer 2017, 65 PMID: 28926679, DOI: 10.1002/pbc.26826.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMedical MarijuanaNeoplasmsConceptsMedical marijuanaPediatric oncologyCancer-related symptomsPediatric oncology patientsSupportive care agentsMechanism of actionSupportive carePediatric patientsOncology patientsSerious illnessCare agentsPatientsOncologyMarijuanaPotential benefitsPurported benefitsFuture investigationsReviewSymptomsIllnessCancerCareInfluence of early phase clinical trial enrollment on patterns of end‐of‐life care for children with advanced cancer
Ananth P, Monsereenusorn C, Ma C, Al‐Sayegh H, Wolfe J, Rodriguez‐Galindo C. Influence of early phase clinical trial enrollment on patterns of end‐of‐life care for children with advanced cancer. Pediatric Blood & Cancer 2017, 65 PMID: 28771913, DOI: 10.1002/pbc.26748.Peer-Reviewed Original ResearchConceptsEarly phase clinical trialsTrial enrollmentAdvanced cancerHealthcare utilizationLife careRetrospective cohort studyPediatric oncology patientsClinical trial enrollmentPhase clinical trialsPatterns of endNeP patientsBaseline characteristicsCohort studyOncology patientsEP patientsPPC consultationClinical trialsCare receiptPatientsCancerEnrollmentCareFuture studiesChildrenEOLCTrends in Hospital Utilization and Costs among Pediatric Palliative Care Recipients
Ananth P, Melvin P, Berry JG, Wolfe J. Trends in Hospital Utilization and Costs among Pediatric Palliative Care Recipients. Journal Of Palliative Medicine 2017, 20: 946-953. PMID: 28453361, DOI: 10.1089/jpm.2016.0496.Peer-Reviewed Original ResearchConceptsPediatric palliative carePPC consultationED visitsHospital admissionHospital costsHospital utilizationAnnual hospital admission rateIntensive care unit usePalliative care recipientsPercent of patientsRetrospective cohort studyAnnual ED visitsEmergency department visitsHospital admission ratesQuaternary children's hospitalYears of agePPC involvementCohort studyDepartment visitsMedian ageED useSingle centerChildren's HospitalPalliative careIll children
2016
Liposomal doxorubicin: Effective treatment for pediatric desmoid fibromatosis
Ananth P, Werger A, Voss S, Rodriguez‐Galindo C, Janeway KA. Liposomal doxorubicin: Effective treatment for pediatric desmoid fibromatosis. Pediatric Blood & Cancer 2016, 64: e26375. PMID: 27905688, DOI: 10.1002/pbc.26375.Peer-Reviewed Original ResearchConceptsProgression-free intervalLiposomal doxorubicinDesmoid fibromatosisLonger progression-free intervalMedian progression-free intervalRetrospective case seriesImportant treatment optionClinical responseMedical therapyCase seriesTumor sizeTreatment optionsEffective treatmentFibromatosisTreatmentChildrenMedications
2015
Hospital Use in the Last Year of Life for Children With Life-Threatening Complex Chronic Conditions
Ananth P, Melvin P, Feudtner C, Wolfe J, Berry JG. Hospital Use in the Last Year of Life for Children With Life-Threatening Complex Chronic Conditions. Pediatrics 2015, 136: 938-946. PMID: 26438707, PMCID: PMC4621793, DOI: 10.1542/peds.2015-0260.Peer-Reviewed Original ResearchConceptsComplex chronic conditionsHospital useChronic conditionsPediatric Health Information System databaseHealth Information System databaseClinical Modification codesUS children's hospitalsHospital resource useCostly health careHealth care experiencesHematologic/Terminal admissionEnd of lifeUnderwent surgeryHospital daysHospital admissionImmunologic conditionsChildren's HospitalHospital costsInformation System databaseRetrospective analysisInternational ClassificationCare experiencesAdmissionHealth care