2024
Harnessing Natural Language Processing to Assess Quality of End-of-Life Care for Children With Cancer
Lindsay M, de Oliveira S, Sciacca K, Lindvall C, Ananth P. Harnessing Natural Language Processing to Assess Quality of End-of-Life Care for Children With Cancer. JCO Clinical Cancer Informatics 2024, 8: e2400134. PMID: 39265122, PMCID: PMC11407740, DOI: 10.1200/cci.24.00134.Peer-Reviewed Original ResearchConceptsEnd-of-life carePalliative care consultationGoals of careLocation of deathProportion of decedentsDocumented discussionCare consultationEvidence-based quality measuresMeasure quality of careGold standard manual chart reviewQuality measuresQuality of careEnd of lifeContent of clinical notesLife-sustaining treatmentEnd-of-lifeManual chart reviewCancer decedentsEfficient quality measureCohort of childrenAssess qualityMulti-center researchQuality improvementMeasure qualityCare
2022
Survey of Pediatric Palliative Care Quality Improvement Training, Activities, and Barriers
Bogetz JF, Johnston E, Ananth P, Patneaude A, Workgroup T, Thienprayoon R, Rosenberg A. Survey of Pediatric Palliative Care Quality Improvement Training, Activities, and Barriers. Journal Of Pain And Symptom Management 2022, 64: e123-e131. PMID: 35577143, DOI: 10.1016/j.jpainsymman.2022.04.182.Peer-Reviewed Original ResearchConceptsPediatric palliative careQI activitiesHigh-quality pediatric palliative careQI effortsQI workPediatrics Task ForceHalf of participantsQuality improvement activitiesPalliative careQuality improvement trainingEducation/trainingSerious illnessImprovement NetworkElectronic surveyQI trainingOne-thirdHours totalTwo-thirdsCliniciansClinical disciplinesOne-quarterResearch NetworkTask ForceDedicated staffStandardized measures
2020
Patterns of medication use at end of life by pediatric inpatients with cancer
Prozora S, Shabanova V, Ananth P, Pashankar F, Kupfer GM, Massaro SA, Davidoff AJ. Patterns of medication use at end of life by pediatric inpatients with cancer. Pediatric Blood & Cancer 2020, 68: e28837. PMID: 33306281, DOI: 10.1002/pbc.28837.Peer-Reviewed Original ResearchConceptsMedication usePediatric inpatientsVizient Clinical Database/Resource ManagerHematopoietic stem cell transplantLife-sustaining medicationsMedication utilization patternsSymptom management medicationsUse of opioidsStem cell transplantIntensive care unitLength of stayAcademic medical centerResource use dataLast weekWarrants further studyEvidence-based approachVasopressor useEnd of lifeCare unitCell transplantMedication categoriesResuscitate statusRetrospective studyMalignancy typeOdds ratioParent and patient perceptions of medical marijuana in the childhood cancer context
Ananth P, Revette A, Reed‐Weston A, Das P, Wolfe J. Parent and patient perceptions of medical marijuana in the childhood cancer context. Pediatric Blood & Cancer 2020, 68: e28830. PMID: 33258215, DOI: 10.1002/pbc.28830.Peer-Reviewed Original ResearchConceptsParents of childrenInductive coding approachesPsychological effectsGreater side effect profileParents' perceptionsPediatric cancer careMedical marijuanaParticipantsLack of researchParentsMM useRobust clinical trial dataPerceptionSupportive care medicationsCancer-directed therapyFuture research initiativesSide effect profileYoung adult patientsRelief of nauseaComprehensive cancer centerMarijuanaClinical trial dataFramework analysisAYAsQualitative study
2018
Provider Perspectives on Use of Medical Marijuana in Children With Cancer
Ananth P, Ma C, Al-Sayegh H, Kroon L, Klein V, Wharton C, Hallez E, Braun I, Michelson K, Rosenberg AR, London W, Wolfe J. Provider Perspectives on Use of Medical Marijuana in Children With Cancer. Pediatrics 2018, 141: e20170559. PMID: 29233937, PMCID: PMC5744275, DOI: 10.1542/peds.2017-0559.Peer-Reviewed Original ResearchConceptsPediatric oncology providersMedical marijuanaOncology providersMM useProvider perspectivesCancer-directed therapyPercent of providersCross-sectional surveyLogistic regression modelsWilcoxon rank testSupportive careMedian ageOral formulationMM practiceSerious illnessMost providersGroup comparisonsCancerPrevious monthRank testState-specific regulationsChildrenRegression modelsImportant barriersGreatest barrier
2017
Medical marijuana in pediatric oncology: A review of the evidence and implications for practice
Ananth P, Reed‐Weston A, Wolfe J. Medical marijuana in pediatric oncology: A review of the evidence and implications for practice. Pediatric Blood & Cancer 2017, 65 PMID: 28926679, DOI: 10.1002/pbc.26826.Peer-Reviewed Original ResearchConceptsMedical marijuanaPediatric oncologyCancer-related symptomsPediatric oncology patientsSupportive care agentsMechanism of actionSupportive carePediatric patientsOncology patientsSerious illnessCare agentsPatientsOncologyMarijuanaPotential benefitsPurported benefitsFuture investigationsReviewSymptomsIllnessCancerCareInfluence of early phase clinical trial enrollment on patterns of end‐of‐life care for children with advanced cancer
Ananth P, Monsereenusorn C, Ma C, Al‐Sayegh H, Wolfe J, Rodriguez‐Galindo C. Influence of early phase clinical trial enrollment on patterns of end‐of‐life care for children with advanced cancer. Pediatric Blood & Cancer 2017, 65 PMID: 28771913, DOI: 10.1002/pbc.26748.Peer-Reviewed Original ResearchConceptsEarly phase clinical trialsTrial enrollmentAdvanced cancerHealthcare utilizationLife careRetrospective cohort studyPediatric oncology patientsClinical trial enrollmentPhase clinical trialsPatterns of endNeP patientsBaseline characteristicsCohort studyOncology patientsEP patientsPPC consultationClinical trialsCare receiptPatientsCancerEnrollmentCareFuture studiesChildrenEOLCTrends in Hospital Utilization and Costs among Pediatric Palliative Care Recipients
Ananth P, Melvin P, Berry JG, Wolfe J. Trends in Hospital Utilization and Costs among Pediatric Palliative Care Recipients. Journal Of Palliative Medicine 2017, 20: 946-953. PMID: 28453361, DOI: 10.1089/jpm.2016.0496.Peer-Reviewed Original ResearchConceptsPediatric palliative carePPC consultationED visitsHospital admissionHospital costsHospital utilizationAnnual hospital admission rateIntensive care unit usePalliative care recipientsPercent of patientsRetrospective cohort studyAnnual ED visitsEmergency department visitsHospital admission ratesQuaternary children's hospitalYears of agePPC involvementCohort studyDepartment visitsMedian ageED useSingle centerChildren's HospitalPalliative careIll children
2016
Liposomal doxorubicin: Effective treatment for pediatric desmoid fibromatosis
Ananth P, Werger A, Voss S, Rodriguez‐Galindo C, Janeway KA. Liposomal doxorubicin: Effective treatment for pediatric desmoid fibromatosis. Pediatric Blood & Cancer 2016, 64: e26375. PMID: 27905688, DOI: 10.1002/pbc.26375.Peer-Reviewed Original ResearchConceptsProgression-free intervalLiposomal doxorubicinDesmoid fibromatosisLonger progression-free intervalMedian progression-free intervalRetrospective case seriesImportant treatment optionClinical responseMedical therapyCase seriesTumor sizeTreatment optionsEffective treatmentFibromatosisTreatmentChildrenMedications
2015
Hospital Use in the Last Year of Life for Children With Life-Threatening Complex Chronic Conditions
Ananth P, Melvin P, Feudtner C, Wolfe J, Berry JG. Hospital Use in the Last Year of Life for Children With Life-Threatening Complex Chronic Conditions. Pediatrics 2015, 136: 938-946. PMID: 26438707, PMCID: PMC4621793, DOI: 10.1542/peds.2015-0260.Peer-Reviewed Original ResearchConceptsComplex chronic conditionsHospital useChronic conditionsPediatric Health Information System databaseHealth Information System databaseClinical Modification codesUS children's hospitalsHospital resource useCostly health careHealth care experiencesHematologic/Terminal admissionEnd of lifeUnderwent surgeryHospital daysHospital admissionImmunologic conditionsChildren's HospitalHospital costsInformation System databaseRetrospective analysisInternational ClassificationCare experiencesAdmissionHealth care
2014
Neuroblastoma Presenting as Facial Nerve Palsy and Bulging Tympanic Membrane
Bernson-Leung M, Ananth P, Shusterman S. Neuroblastoma Presenting as Facial Nerve Palsy and Bulging Tympanic Membrane. Clinical Pediatrics 2014, 54: 183-185. PMID: 24817076, DOI: 10.1177/0009922814534314.Peer-Reviewed Original Research