2018
Oncologic Safety of Prophylactic Nipple-Sparing Mastectomy in a Population With BRCA Mutations: A Multi-institutional Study
Jakub J, Peled A, Gray R, Greenup R, Kiluk J, Sacchini V, McLaughlin S, Tchou J, Vierkant R, Degnim A, Willey S. Oncologic Safety of Prophylactic Nipple-Sparing Mastectomy in a Population With BRCA Mutations: A Multi-institutional Study. JAMA Surgery 2018, 153: 123-129. PMID: 28903167, PMCID: PMC5838709, DOI: 10.1001/jamasurg.2017.3422.Peer-Reviewed Original ResearchConceptsProphylactic nipple-sparing mastectomyNipple-sparing mastectomyRisk-reducing mastectomyPrimary breast cancerBRCA mutationsBreast cancerOncologic safetyContralateral risk-reducing mastectomyNew primary breast cancerOccult primary breast cancerCancer risk-reducing strategiesIpsilateral breast cancerNew breast cancersBreast cancer eventsCohort of patientsNipple-sparing mastectomiesPrimary outcome measureBRCA1/2 mutation carriersFree nipple graftSuperior cosmetic outcomesEvidence-based dataHealth care professionalsMulti-institutional studyNipple-areolar complexProphylactic side
2016
Surgeons’ Perspectives of Contralateral Prophylactic Mastectomy
Bellavance E, Peppercorn J, Kronsberg S, Greenup R, Keune J, Lynch J, Collyar D, Magder L, Tilburt J, Hlubocky F, Yao K. Surgeons’ Perspectives of Contralateral Prophylactic Mastectomy. Annals Of Surgical Oncology 2016, 23: 2779-2787. PMID: 27169770, DOI: 10.1245/s10434-016-5253-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAttitude of Health PersonnelComprehensionFemaleGenes, BRCA1Genes, BRCA2HumansMaleMedical OveruseMiddle AgedPatientsPractice Patterns, Physicians'Prophylactic MastectomyRisk AssessmentRisk FactorsSurgical OncologySurveys and QuestionnairesUnilateral Breast NeoplasmsConceptsContralateral prophylactic mastectomyOncologic benefitProphylactic mastectomyBreast cancerBenefits of CPMUnfavorable risk/benefit ratioUse of CPMRisk/benefit ratioAverage-risk patientsDeleterious BRCA mutationsProportion of surgeonsInadequate patient understandingPercent of respondentsMedian ageBRCA mutationsBreast diseaseBreast surgeonsPractice patternsRelative riskPatient understandingCommon reasonMost surgeonsMethodsA surveyPatientsSurgeons