2022
Treatment Sequencing Patterns and Associated Direct Medical Costs of Metastatic Breast Cancer Care in the United States, 2011 to 2021
Chehayeb R, Hood A, Wang X, Miksad R, Mougalian S, Lustberg M, Wang S, Greenup R, Pusztai L, Kunst N. Treatment Sequencing Patterns and Associated Direct Medical Costs of Metastatic Breast Cancer Care in the United States, 2011 to 2021. JAMA Network Open 2022, 5: e2244204. PMID: 36445704, PMCID: PMC9709649, DOI: 10.1001/jamanetworkopen.2022.44204.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerErbB2-positive metastatic breast cancerHR-positive metastatic breast cancerLines of therapyMBC subtypesDrug costsBreast cancerMedical costsHuman epidermal growth factor receptor 2 receptor statusMBC treatmentERBB2-negative metastatic breast cancerAssociated direct medical costsEarly-stage breast cancerHormone receptorsFlatiron Health databaseMetastatic recurrence ratesDifferent drug regimensBreast cancer careData of patientsDirect medical costsNovel adjuvant therapySupportive care drugsOutcomes of interestCost-effectiveness analysisAdjuvant therapy
2018
Axillary Nodal Evaluation in Elderly Breast Cancer Patients: Potential Effects on Treatment Decisions and Survival
Tamirisa N, Thomas S, Fayanju O, Greenup R, Rosenberger L, Hyslop T, Hwang E, Plichta J. Axillary Nodal Evaluation in Elderly Breast Cancer Patients: Potential Effects on Treatment Decisions and Survival. Annals Of Surgical Oncology 2018, 25: 2890-2898. PMID: 29968029, PMCID: PMC6404232, DOI: 10.1245/s10434-018-6595-2.Peer-Reviewed Original ResearchConceptsBreast cancer patientsElderly breast cancer patientsCN0 breast cancerOverall survivalNodal surgeryCancer patientsAxillary surgeryElderly patientsTreatment decisionsBreast cancerCharlson-Deyo comorbidity scoreCN0 breast cancer patientsSurgical lymph node evaluationCox proportional hazards modelAdjuvant therapy decisionsAdjuvant therapy receiptAxillary nodal evaluationLymph node evaluationNational Cancer DatabaseYear of diagnosisWorse overall survivalEstrogen receptor statusLong-term outcomesSubsequent treatment decisionsProportional hazards modelThe Effect of Hospital Volume on Breast Cancer Mortality
Greenup R, Obeng-Gyasi S, Thomas S, Houck K, Lane W, Blitzblau R, Hyslop T, Hwang E. The Effect of Hospital Volume on Breast Cancer Mortality. Annals Of Surgery 2018, 267: 375-381. PMID: 27893532, PMCID: PMC5994238, DOI: 10.1097/sla.0000000000002095.Peer-Reviewed Original ResearchConceptsHigh-volume centersNational Cancer Data BaseHospital volumeVolume centersBreast cancerHazard ratioImproved survivalStage 0Case volumeMultivariable Cox proportional hazards modelsMultidisciplinary breast cancer treatmentMultivariable Cox proportional hazardsSurgeons National Cancer Data BaseCox proportional hazards modelAnnual hospital volumeLess common cancersUnilateral breast cancerBreast cancer mortalityBreast cancer patientsCubic spline analysisLog-rank testBreast cancer treatmentCox proportional hazardsProportional hazards modelHigher case volume
2016
Surgeons’ Perspectives of Contralateral Prophylactic Mastectomy
Bellavance E, Peppercorn J, Kronsberg S, Greenup R, Keune J, Lynch J, Collyar D, Magder L, Tilburt J, Hlubocky F, Yao K. Surgeons’ Perspectives of Contralateral Prophylactic Mastectomy. Annals Of Surgical Oncology 2016, 23: 2779-2787. PMID: 27169770, DOI: 10.1245/s10434-016-5253-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAttitude of Health PersonnelComprehensionFemaleGenes, BRCA1Genes, BRCA2HumansMaleMedical OveruseMiddle AgedPatientsPractice Patterns, Physicians'Prophylactic MastectomyRisk AssessmentRisk FactorsSurgical OncologySurveys and QuestionnairesUnilateral Breast NeoplasmsConceptsContralateral prophylactic mastectomyOncologic benefitProphylactic mastectomyBreast cancerBenefits of CPMUnfavorable risk/benefit ratioUse of CPMRisk/benefit ratioAverage-risk patientsDeleterious BRCA mutationsProportion of surgeonsInadequate patient understandingPercent of respondentsMedian ageBRCA mutationsBreast diseaseBreast surgeonsPractice patternsRelative riskPatient understandingCommon reasonMost surgeonsMethodsA surveyPatientsSurgeons
2015
Diagnostic Value of Ultrasound in Female Patients With Nipple Discharge.
Bahl M, Baker J, Greenup R, Ghate S. Diagnostic Value of Ultrasound in Female Patients With Nipple Discharge. American Journal Of Roentgenology 2015, 205: 203-8. PMID: 26102400, DOI: 10.2214/ajr.14.13354.Peer-Reviewed Original ResearchConceptsPathologic nipple dischargeNipple dischargeInvasive adenocarcinomaSurgical excisionEvaluation of patientsDetection of DCISNormal sonographic findingsSpecificity of mammographySpecificity of ultrasoundUseful diagnostic toolContribution of ultrasoundBilateral mammographyFemale patientsPathologic featuresRadiologic findingsRetrospective reviewDuctal carcinomaSonographic findingsPathologic resultsStudy populationPatientsRoutine evaluationDiagnostic valueAdenocarcinomaUltrasoundA Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins
Nichols B, Schindler C, Brown J, Wilke L, Mulvey C, Krieger M, Gallagher J, Geradts J, Greenup R, Von Windheim J, Ramanujam N. A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins. PLOS ONE 2015, 10: e0127525. PMID: 26076123, PMCID: PMC4468201, DOI: 10.1371/journal.pone.0127525.Peer-Reviewed Original ResearchConceptsBreast tumor marginsOptical property mapsDiffuse optical spectroscopyImaging systemWhite LED sourceDiffuse reflectance imagesOptical spectroscopyDistribution function analysisFiber optic probeTurbid mediaEmpirical cumulative distribution function (eCDF) analysisLarge tissue areasLED sourcesScattering coefficientSub-pixel resolutionProbe-tissue interfaceIntra-operative toolMorphological landscapeOptic probeImaging platformTime scalesProperty mapsImproved sensitivityEstimation errorSpectrograph
2012
Cost Comparison of Radiation Treatment Options After Lumpectomy for Breast Cancer
Greenup R, Camp M, Taghian A, Buckley J, Coopey S, Gadd M, Hughes K, Specht M, Smith B. Cost Comparison of Radiation Treatment Options After Lumpectomy for Breast Cancer. Annals Of Surgical Oncology 2012, 19: 3275-3281. PMID: 22851048, DOI: 10.1245/s10434-012-2546-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrachytherapyBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularCombined Modality TherapyCosts and Cost AnalysisFemaleFollow-Up StudiesHealth Care CostsHumansMastectomy, SegmentalMiddle AgedNeoplasm GradingNeoplasm InvasivenessPrognosisRetrospective StudiesConceptsWhole breast radiation therapyBreast cancerRT optionsExternal-beam partial breast irradiationLeukemia Group B 9343MethodsAn institutional review boardResultsMedian patient ageCurrent Procedural Terminology codesMedian tumor sizeInvasive ductal cancerSitu breast cancerPartial breast irradiationProcedural Terminology codesRadiation treatment optionsInstitutional review boardC-RTBackgroundRadiation therapyRT regimensBreast conservationDuctal cancerLobular cancerMixed histologyPatient ageRetrospective reviewTumor histology