2016
A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer
Whitley M, Cardona D, Lazarides A, Spasojevic I, Ferrer J, Cahill J, Lee C, Snuderl M, Blazer D, Hwang E, Greenup R, Mosca P, Mito J, Cuneo K, Larrier N, O'Reilly E, Riedel R, Eward W, Strasfeld D, Fukumura D, Jain R, Lee W, Griffith L, Bawendi M, Kirsch D, Brigman B. A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Science Translational Medicine 2016, 8: 320ra4. PMID: 26738797, PMCID: PMC4794335, DOI: 10.1126/scitranslmed.aad0293.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasLocal recurrenceTumor bedClinical trialsIntravenous injectionPhase 1 clinical trialHuman phase 1 clinical trialCo-clinical studiesMicroscopic residual cancerPositive surgical marginsFuture clinical trialsCo-clinical trialsRates of reexcisionAdjuvant therapyResidual cancerSurgical marginsTreatment failureTissue sarcomasBreast cancerCommon causeIntraoperative detectionMouse modelPharmacokinetic profileSolid tumorsCancer
2015
A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins
Nichols B, Schindler C, Brown J, Wilke L, Mulvey C, Krieger M, Gallagher J, Geradts J, Greenup R, Von Windheim J, Ramanujam N. A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins. PLOS ONE 2015, 10: e0127525. PMID: 26076123, PMCID: PMC4468201, DOI: 10.1371/journal.pone.0127525.Peer-Reviewed Original ResearchConceptsBreast tumor marginsOptical property mapsDiffuse optical spectroscopyImaging systemWhite LED sourceDiffuse reflectance imagesOptical spectroscopyDistribution function analysisFiber optic probeTurbid mediaEmpirical cumulative distribution function (eCDF) analysisLarge tissue areasLED sourcesScattering coefficientSub-pixel resolutionProbe-tissue interfaceIntra-operative toolMorphological landscapeOptic probeImaging platformTime scalesProperty mapsImproved sensitivityEstimation errorSpectrograph