2024
Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology consensus review on diagnosis, management, and future directions
Lim-Fat M, Bennett J, Ostrom Q, Touat M, Franceschi E, Schulte J, Bindra R, Fangusaro J, Dhall G, Nicholson J, Jackson S, Davidson T, Calaminus G, Robinson G, Whittle J, Hau P, Ramaswamy V, Pajtler K, Rudà R, Foreman N, Hervey-Jumper S, Das S, Dirks P, Bi W, Huang A, Merchant T, Fouladi M, Aldape K, Van den Bent M, Packer R, Miller J, Reardon D, Chang S, Haas-Kogan D, Tabori U, Hawkins C, Monje M, Wen P, Bouffet E, Yeo K. Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology consensus review on diagnosis, management, and future directions. Neuro-Oncology 2024, noae186. PMID: 39441704, DOI: 10.1093/neuonc/noae186.Peer-Reviewed Original ResearchSociety for Neuro-OncologyCentral nervous systemTumor typesCentral nervous system germ cell tumorsCare of AYA patientsManagement of CNS tumorsBrain tumorsCause of cancer-related deathCentral nervous system tumorsAdvanced molecular testingGerm cell tumorsUnique tumor biologyNervous system tumorsCancer-related deathsMalignant brain tumorsHistological diagnosisYoung adultsWHO classificationAYA populationCell tumorsCNS tumorsTargeted therapyTumor biologyAYA patientsConsensus reviewDNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology
Rahman R, Shi D, Reitman Z, Hamerlik P, de Groot J, Haas-Kogan D, D’Andrea A, Sulman E, Tanner K, Agar N, Sarkaria J, Tinkle C, Bindra R, Mehta M, Wen P. DNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology. Neuro-Oncology 2024, 26: 1367-1387. PMID: 38770568, PMCID: PMC11300028, DOI: 10.1093/neuonc/noae072.Peer-Reviewed Original ResearchConsensus reviewDNA damage responseIDH wild-type glioblastomaIDH-mutant gliomasClinical trial design considerationsMechanisms of resistanceTrial design considerationsCombination therapyDevelopment of DDR inhibitorsDNA damage response pathwayPreclinical modelsDamage responseDDR inhibitorsNeuro-oncologyBrain tumorsBiomarker developmentTherapyResponse to DNA damageDNA damageTranslational effortsTumor
2020
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro-Oncology 2020, 22: 1073-1113. PMID: 32328653, PMCID: PMC7594557, DOI: 10.1093/neuonc/noaa106.Peer-Reviewed Original ResearchConceptsNeuro-oncologyConsensus reviewCurrent managementMalignant primary brain tumorIsocitrate dehydrogenase-wildtype glioblastomaPrimary brain tumorsNovel therapiesViral therapyBrain tumorsImportant causeMolecular pathogenesisMolecular therapyEuropean AssociationTherapyEuropean SocietyCommon formGlioblastomaWildtype glioblastomaTumorsFuture directionsImportant advancesImmunotherapyMorbidityPatientsDNA damage response
2019
Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review
Gallitto M, Lazarev S, Wasserman I, Stafford JM, Wolden SL, Terezakis SA, Bindra RS, Bakst RL. Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review. Advances In Radiation Oncology 2019, 4: 520-531. PMID: 31360809, PMCID: PMC6639749, DOI: 10.1016/j.adro.2019.03.009.Peer-Reviewed Original ResearchDiffuse intrinsic pontine gliomaIntrinsic pontine gliomaMedian overall survivalOverall survivalRadiation therapyPontine gliomaSystematic reviewSystemic therapyPrimary pediatric brain tumorsMainstay of treatmentSalvage radiation therapyConcomitant systemic therapyPediatric brain tumorsAppropriate treatment approachLarge systematic reviewGreat clinical needDIPG treatmentMedian OSRT regimensRetrospective seriesInitial diagnosisGlioma radiotherapyTreatment strategiesBrain tumorsTreatment approaches
2018
Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib
Marks AM, Bindra RS, DiLuna ML, Huttner A, Jairam V, Kahle KT, Kieran MW. Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib. Pediatric Blood & Cancer 2018, 65: e26969. PMID: 29380516, DOI: 10.1002/pbc.26969.Peer-Reviewed Original ResearchConceptsAnaplastic gangliogliomaBRAF/MEK inhibitor combinationsBRAF V600ESubsequent tumor responseDabrafenib/trametinibLarge clinical trialsSquamous cell carcinomaMEK inhibitor combinationsSignificant side effectsSignificant skin reactionsCell carcinomaCase reportSkin reactionsTumor responseClinical trialsBrain tumorsInhibitor combinationsSide effectsAdolescent femalesGangliogliomaTrametinibPrevious reactionsV600EMonotherapyRash
2015
Advances in Radiation Therapy in Pediatric Neuro-oncology
Bindra RS, Wolden SL. Advances in Radiation Therapy in Pediatric Neuro-oncology. Journal Of Child Neurology 2015, 31: 506-516. PMID: 26271789, DOI: 10.1177/0883073815597758.Peer-Reviewed Original ResearchConceptsPediatric central nervous system tumorsCentral nervous system tumorsNervous system tumorsSystem tumorsRadiation therapyPediatric neuro-oncologyLong-term survivalEffective therapyTreatment protocolNeuro-oncologyBrain tumorsTherapyPrecision treatmentTumorsMolecular classificationMore childrenHealthy tissueImage guidanceProton therapyLess exposureTreatmentDoses