2009
Targeting the DNA damage response for cancer therapy
Powell SN, Bindra RS. Targeting the DNA damage response for cancer therapy. DNA Repair 2009, 8: 1153-1165. PMID: 19501553, DOI: 10.1016/j.dnarep.2009.04.011.Peer-Reviewed Original ResearchConceptsDNA damage responseCell cycle checkpointsDouble-strand breaksGenome integrityGenomic integrityHistone modificationsDamage responseCycle checkpointsDNA repairKey proteinsDNA damageAnti-cancer agentsHuman tumorsNew anti-cancer agentsPathwayCancer therapyTumor cellsCheckpointProteinTherapeutic interventionsRepairIntegrityDefectsCellsAppropriate response
2006
CHK2-Dependent Phosphorylation of BRCA1 in Hypoxia
Gibson SL, Bindra RS, Glazer PM. CHK2-Dependent Phosphorylation of BRCA1 in Hypoxia. Radiation Research 2006, 166: 646-651. PMID: 17007555, DOI: 10.1667/rr0660.1.Peer-Reviewed Original ResearchConceptsCell cycle checkpoint regulationATM-dependent mannerChk2-dependent phosphorylationDNA repair factorsHypoxic stressCheckpoint kinaseCheckpoint regulationRepair factorsMammalian cellsDNA repairBRCA1 proteinDownstream targetsNovel roleChk2 expressionPhosphorylationChk2Pathway activationCritical roleBRCA1Diverse spectrumExpressionTumor microenvironmentActivationKinaseProtein