Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells
Ruiz-Ramos R, López-Carrillo L, Albores A, Hernández-Ramírez RU, Cebrian ME. Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells. Toxicology And Applied Pharmacology 2009, 241: 269-274. PMID: 19766132, DOI: 10.1016/j.taap.2009.09.006.Peer-Reviewed Original ResearchConceptsC-Myc protein levelsProtein levelsC-MycInduction of genesMCF-7 cellsHigher DNA synthesis rateMTHFR protein levelsAlters cell cycleBreast epithelial cellsArsenite treatmentGrowth regulationMethylenetetrahydrofolate reductaseCell cycleC-Myc overexpressionFolate cycleDNA synthesis rateBrdU-stained cellsEffects of arsenicCell proliferationHuman populationSodium arseniteEpithelial cellsCell viabilityMT1/2Arsenite concentrationGastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers
Galván-Portillo MV, Cantoral A, Oñate-Ocaña LF, Chen J, Herrera-Goepfert R, Torres-Sanchez L, Hernandez-Ramirez RU, Palma-Coca O, López-Carrillo L. Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers. European Journal Of Nutrition 2009, 48: 269-276. PMID: 19288150, DOI: 10.1007/s00394-009-0010-5.Peer-Reviewed Original ResearchConceptsOne-carbon metabolismDNA methylationMTHFR 677 TT genotypeImportant epigenetic processDietary intakeTT genotypePopulation-based case-control studyGC riskMethylenetetrahydrofolate reductaseFood frequency questionnaireTranscriptional controlHuman genomeCase-control studySex-matched controlsEpigenetic processesPCR-RFLP analysisMTHFR 677 CCMTHFR 677 CBorderline of significanceKey enzymeIntake of nutrientsMetabolic pathwaysCancer initiationMethyl-donor nutrientsMethylation