2020
Timing of Antiretroviral Therapy Initiation and Risk of Cancer Among Persons Living With Human Immunodeficiency Virus
Silverberg MJ, Leyden W, Hernández-Ramírez RU, Qin L, Lin H, Justice AC, Hessol NA, Achenbach CJ, D’Souza G, Engels EA, Althoff KN, Mayor AM, Sterling TR, Kitahata MM, Bosch RJ, Saag MS, Rabkin CS, Horberg MA, Gill MJ, Grover S, Mathews WC, Li J, Crane HM, Gange SJ, Lau B, Moore RD, Dubrow R, Neugebauer RS. Timing of Antiretroviral Therapy Initiation and Risk of Cancer Among Persons Living With Human Immunodeficiency Virus. Clinical Infectious Diseases 2020, 72: 1900-1909. PMID: 32785640, PMCID: PMC8315132, DOI: 10.1093/cid/ciaa1046.Peer-Reviewed Original ResearchConceptsVirus-related cancersEarly antiretroviral therapyHuman immunodeficiency virusAntiretroviral therapyART initiationImmunodeficiency virusNorth American AIDS Cohort CollaborationART-naive PLWHEarly ART initiationAntiretroviral therapy initiationHIV transmission riskNon-Hodgkin lymphomaCancer registry linkageRisk of cancerMarginal structural modelsRace/ethnicityCohort CollaborationTherapy initiationChart reviewIncident cancerRegistry linkageViral hepatitisTime-dependent confoundingCancer groupViral etiology
2017
Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study
Hernández-Ramírez RU, Shiels MS, Dubrow R, Engels EA. Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study. The Lancet HIV 2017, 4: e495-e504. PMID: 28803888, PMCID: PMC5669995, DOI: 10.1016/s2352-3018(17)30125-x.Peer-Reviewed Original ResearchConceptsStandardised incidence ratiosRegistry linkage studyVirus-related cancersCancer riskGeneral populationCancer RegistryModern antiretroviral therapy (ART) eraAntiretroviral therapy eraPopulation-based HIVUSA general populationCohort of HIVNon-Hodgkin lymphomaDiagnosis of cancerNational Cancer InstituteSIR differenceTherapy eraCancer overallIncident cancerMultivariable adjustmentART exposureIncidence ratiosAIDS onsetCommon cancerLung cancerKaposi's sarcoma