2013
Arsenic Exposure and Calpain-10 Polymorphisms Impair the Function of Pancreatic Beta-Cells in Humans: A Pilot Study of Risk Factors for T2DM
Díaz-Villaseñor A, Cruz L, Cebrián A, Hernández-Ramírez RU, Hiriart M, García-Vargas G, Bassol S, Sordo M, Gandolfi AJ, Klimecki WT, López-Carillo L, Cebrián ME, Ostrosky-Wegman P. Arsenic Exposure and Calpain-10 Polymorphisms Impair the Function of Pancreatic Beta-Cells in Humans: A Pilot Study of Risk Factors for T2DM. PLOS ONE 2013, 8: e51642. PMID: 23349674, PMCID: PMC3551951, DOI: 10.1371/journal.pone.0051642.Peer-Reviewed Original ResearchConceptsBeta-cell functionLower beta-cell functionSNP-43Risk factorsInsulin sensitivitySNP-44IAs exposureSingle nucleotide polymorphismsChronic exposureCAPN-10Type 2 diabetes mellitusOutcomes of T2DMCalpain-10 polymorphismsGenetic risk factorsPancreatic beta cellsAction of insulinCalpain-10 geneDiabetes mellitusInverse associationInsulin secretionT2DMBeta cellsRisk genotypesArsenic exposurePilot study
2012
Capsaicin consumption, Helicobacter pylori CagA status and IL1B-31C>T genotypes: A host and environment interaction in gastric cancer
López-Carrillo L, Camargo MC, Schneider BG, Sicinschi LA, Hernández-Ramírez RU, Correa P, Cebrian ME. Capsaicin consumption, Helicobacter pylori CagA status and IL1B-31C>T genotypes: A host and environment interaction in gastric cancer. Food And Chemical Toxicology 2012, 50: 2118-2122. PMID: 22414649, PMCID: PMC3636974, DOI: 10.1016/j.fct.2012.02.043.Peer-Reviewed Original ResearchConceptsGastric cancerCagA statusHelicobacter pylori CagA statusGC riskH. pylori CagA statusConsumption of capsaicinFood frequency questionnaireUnconditional logistic regressionHigh-risk individualsVirulent H. pyloriFrequency questionnaireClinical controlGC patientsRisk individualsT genotypeGene-environment interactionsMortality ratePotential interactionsIL1B -31CH. pyloriSusceptible individualsMortality trendsCapsaicin consumptionLogistic regressionTaqMan assays
2009
Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers
Galván-Portillo MV, Cantoral A, Oñate-Ocaña LF, Chen J, Herrera-Goepfert R, Torres-Sanchez L, Hernandez-Ramirez RU, Palma-Coca O, López-Carrillo L. Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers. European Journal Of Nutrition 2009, 48: 269-276. PMID: 19288150, DOI: 10.1007/s00394-009-0010-5.Peer-Reviewed Original ResearchConceptsOne-carbon metabolismDNA methylationMTHFR 677 TT genotypeImportant epigenetic processDietary intakeTT genotypePopulation-based case-control studyGC riskMethylenetetrahydrofolate reductaseFood frequency questionnaireTranscriptional controlHuman genomeCase-control studySex-matched controlsEpigenetic processesPCR-RFLP analysisMTHFR 677 CCMTHFR 677 CBorderline of significanceKey enzymeIntake of nutrientsMetabolic pathwaysCancer initiationMethyl-donor nutrientsMethylation