1997
Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder
Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 246-254. PMID: 9075465, DOI: 10.1001/archpsyc.1997.01830150070011.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdministration of yohimbineNorepinephrine releaseHealthy subjectsHealthy age-matched control subjectsAge-matched control subjectsStress disorderDouble-blind fashionPositron emission tomography (PET) measurementsBrain metabolic responsesCerebral metabolic correlatesBrain norepinephrine releaseSymptoms of anxietyPositron emission tomographyBrain metabolismControl subjectsYohimbine administrationPreclinical studiesMetabolic correlatesCaudate nucleusPatientsYohimbineVietnam combat veteransEmission tomographyOrbitofrontal cortexMagnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region
1995
MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder
Bremner J, Randall P, Scott T, Bronen R, Seibyl J, Southwick S, Delaney R, McCarthy G, Charney D, Innis R. MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder. American Journal Of Psychiatry 1995, 152: 973-981. PMID: 7793467, PMCID: PMC3233767, DOI: 10.1176/ajp.152.7.973.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCombat-related posttraumatic stress disorderSmaller right hippocampal volumeRight hippocampal volumeVerbal memoryHippocampal volumeStress disorderPTSD patientsShort-term verbal memoryShort-term memoryWechsler Memory ScaleComparison subjectsVietnam combat veteransMemory ScaleCombat veteransYears of educationMagnetic resonance imagingBrain regionsMemoryBrain structuresFunctional deficitsNeurotoxic effectsPsychiatric disordersAlcohol abusePatients