2006
Increased Number of Subcortical Hyperintensities on MRI in Children and Adolescents With Tourettes Syndrome, Obsessive-Compulsive Disorder, and Attention Deficit Hyperactivity Disorder
Amat JA, Bronen RA, Saluja S, Sato N, Zhu H, Gorman DA, Royal J, Peterson BS. Increased Number of Subcortical Hyperintensities on MRI in Children and Adolescents With Tourettes Syndrome, Obsessive-Compulsive Disorder, and Attention Deficit Hyperactivity Disorder. American Journal Of Psychiatry 2006, 163: 1106-1108. PMID: 16741215, PMCID: PMC2367225, DOI: 10.1176/ajp.2006.163.6.1106.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCerebral hyperintensitiesObsessive-compulsive disorderHealthy comparison subjectsTourette syndromeDeficit hyperactivity disorderMagnetic resonance imagesComparison subjectsHyperactivity disorderT2-weighted magnetic resonance imagesChildhood neuropsychiatric disordersSubcortical injuryPatient groupSubcortical hyperintensitiesHyperintensitySyndromeDiagnostic groupsChildhood diagnosisNeuropsychiatric disordersDisordersResonance imagesSubcortexSubjectsChildrenAdolescents
1997
Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse
Bremner JD, Innis RB, Salomon RM, Staib LH, Ng CK, Miller HL, Bronen RA, Krystal JH, Duncan J, Rich D, Price LH, Malison R, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse. JAMA Psychiatry 1997, 54: 364-374. PMID: 9107153, DOI: 10.1001/archpsyc.1997.01830160092012.Peer-Reviewed Original ResearchConceptsCerebral metabolic correlatesDepressive relapseBrain metabolismMajor depressionMiddle frontal gyrusOrbitofrontal cortexTryptophan depletionMetabolic correlatesPositron emission tomography scanningFrontal gyrusRelapse-prone patientsPathogenesis of depressionPositron emission tomography (PET) measurementsSerotonin reuptake inhibitorsSymptoms of patientsPositron emission tomographySingle photon emissionSpecific brain regionsDorsolateral prefrontal cortexReuptake inhibitorsPlasma tryptophanLimbic regionsCaudate nucleusDepressive symptomsPatients