2001
Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites
Abe R, Donnelly S, Peng T, Bucala R, Metz C. Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites. The Journal Of Immunology 2001, 166: 7556-7562. PMID: 11390511, DOI: 10.4049/jimmunol.166.12.7556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood CellsCell DifferentiationCell MovementCells, CulturedCollagenFemaleFibroblastsFibrosisGelsHumansInjections, IntravenousLipopolysaccharide ReceptorsMiceMice, Inbred BALB CReceptors, ChemokineStem Cell TransplantationStem CellsTransforming Growth Factor betaTransforming Growth Factor beta1Wound HealingConceptsCultured fibrocytesTissue injuryChemokine/chemokine receptor interactionsUnique cell surface phenotypeCutaneous tissue injurySecondary lymphoid chemokineAlpha-smooth muscle actinWound healingWound healing myofibroblastsMononuclear cell populationsCCR7 chemokine receptorChemokine receptor interactionsPotent immunostimulatory activitySmooth muscle actinCell surface phenotypeBlood-borne cellsDifferentiation pathwayFibrocyte traffickingLymphoid chemokinesFibrocyte differentiationChemokine receptorsT cellsSurface phenotypePotent stimulusMuscle actin
2000
Peripheral blood fibrocytes: Mesenchymal precursor cells and the pathogenesis of fibrosis
Chesney J, Bucala R. Peripheral blood fibrocytes: Mesenchymal precursor cells and the pathogenesis of fibrosis. Current Rheumatology Reports 2000, 2: 501-505. PMID: 11123104, DOI: 10.1007/s11926-000-0027-5.Peer-Reviewed Original ResearchConceptsPeripheral blood fibrocytesBlood fibrocytesTissue injuryDistinct cell surface phenotypePersistent T-cell activationNaïve T cellsPathogenesis of fibrosisCell surface phenotypeT cell activationCognate immunityAutoimmune disordersConnective tissue cellsImmunohistochemical studyForeign antigensT cellsSurface phenotypeMesenchymal precursor cellsScar formationFibrotic tissueFibrocytesGrowth factorPrecursor cellsNovel populationMatrix depositionInjury
1997
The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ
Chesney J, Bacher M, Bender A, Bucala R. The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6307-6312. PMID: 9177213, PMCID: PMC21045, DOI: 10.1073/pnas.94.12.6307.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Presenting CellsAntigens, CDCell DifferentiationCell MovementCells, CulturedCicatrixCoculture TechniquesCrosses, GeneticFemaleFibroblastsFlow CytometryHIVHIV Core Protein p24HIV Envelope Protein gp120HLA-DR AntigensHumansImmunophenotypingLymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred DBANeutralization TestsSkinT-LymphocytesConceptsNaive T cellsAntigen presentationT cellsHuman fibrocytesDistinct cell surface phenotypePrime naive T cellsPotent antigen-presenting cellsMajor histocompatability complex (MHC) moleculesAdhesion molecules CD11aAntigen-specific immunityProximal lymph nodesPeripheral blood fibrocytesAntigen-presenting cellsCostimulatory molecules CD80T cell proliferationCell surface phenotypeBlood-borne cellsHIV protein p24Dendritic cellsLymph nodesBlood fibrocytesPotent APCsTissue injurySurface phenotypeCutaneous injury