2022
Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection
Trifone C, Baquero L, Czernikier A, Benencio P, Leng L, Laufer N, Quiroga MF, Bucala R, Ghiglione Y, Turk G. Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection. Viruses 2022, 14: 2218. PMID: 36298774, PMCID: PMC9611675, DOI: 10.3390/v14102218.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF stimulationMIF treatmentIL-17AHIV infectionMIF/CD74 axisFounder HIV-1Functionality of CD4Higher IL-17AHigher MIF concentrationsMIF plasma levelsHIV-1 infectionMigration inhibitory factorPossible therapeutic targetMIF concentrationsIntracellular cytokinesR5-tropicCytokine productionIL-1βIL-6IL-8Plasma levelsHealthy donorsViral persistenceT lymphocytes
2020
Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis
Wirtz TH, Reuken PA, Jansen C, Fischer P, Bergmann I, Backhaus C, Emontzpohl C, Reißing J, Brandt EF, Koenen MT, Schneider KM, Schierwagen R, Brol MJ, Chang J, Zimmermann HW, Köse-Vogel N, Eggermann T, Kurth I, Stoppe C, Bucala R, Bernhagen J, Praktiknjo M, Stallmach A, Trautwein C, Trebicka J, Bruns T, Berres ML. Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis. JHEP Reports 2020, 3: 100221. PMID: 33659891, PMCID: PMC7890204, DOI: 10.1016/j.jhepr.2020.100221.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorConcentrations of MIFMigration inhibitory factorTransplant-free survivalAcute decompensationInhibitory factorSystemic inflammationReceptor CD74Serum concentrationsHigher macrophage migration inhibitory factorTransjugular intrahepatic portosystemic shunt insertionInflammatory cytokine macrophage migration inhibitory factorCytokine macrophage migration inhibitory factorHigher MIF concentrationsRight atrial bloodWorsening of ascitesChronic liver failureLiver function parametersShort-term mortalityHigher serum levelsMIF promoter polymorphismsRisk of deathPortal venous bloodInnate immune responseClassical scoring systems