2022
Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice
Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Leng L, Bucala R, Vera PL. Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice. Frontiers In Systems Neuroscience 2022, 16: 882493. PMID: 35645739, PMCID: PMC9135998, DOI: 10.3389/fnsys.2022.882493.Peer-Reviewed Original ResearchHigh mobility group box 1Macrophage migration inhibitory factorBladder painIntravesical fluidOxidative stressLevels of HMGB1Mobility group box 1Bladder oxidative stressFemale C57BL/6 miceMigration inhibitory factorGroup box 1Possible therapeutic strategiesN-acetylcysteine amideBladder edemaMIF antagonismMIF deficiencyHMGB1 concentrationsMicturition frequencyMicturition volumeMIF releaseHMGB1 levelsC57BL/6 miceMicturition parametersHistological signsHistological evidence
2013
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221)
Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows G, Bourdette D, Offner H, Bucala R, Vandenbark A. Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221). The Journal Of Immunology 2013, 190: 67.4-67.4. DOI: 10.4049/jimmunol.190.supp.67.4.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorExperimental autoimmune encephalomyelitisPartial MHC class II constructsCD74 cell-surface expressionMultiple sclerosisCell surface expressionMIF/CD74 interactionMigration inhibitory factorAutoimmune encephalomyelitisAlpha 1 domainInflammatory activityProinflammatory cytokinesHistological signsMIF activityAnti-apoptotic activityImmune systemInhibitory factorEnhanced secretionMHC complexesAntigenic peptidesCD74MIF effectsRandom migrationSurface expressionPivotal regulator