2000
The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle
Benigni F, Atsumi T, Calandra T, Metz C, Echtenacher B, Peng T, Bucala R. The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. Journal Of Clinical Investigation 2000, 106: 1291-1300. PMID: 11086030, PMCID: PMC381433, DOI: 10.1172/jci9900.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementFructosediphosphatesGlucoseGlycolysisHumansLactic AcidLiverMacrophage Migration-Inhibitory FactorsMacrophagesMiceMusclesPhosphofructokinase-2Phosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)RatsTumor Cells, CulturedTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorMigration inhibitory factorTNF-alphaInhibitory factorTNF-alpha knockout miceMediator macrophage migration inhibitory factorAddition of MIFSystemic inflammatory responseSevere metabolic derangementProinflammatory cytokine productionSerum glucose levelsImmune cell activationAnterior pituitary glandPositive allosteric regulatorMetabolic derangementsAutocrine stimuliCytokine productionGlucose disposalImmune cellsSevere infectionsCatabolic effectsInflammatory responseGlucose levelsInsulin releaseCatabolic response
1999
A role for the endocrine and pro‐inflammatory mediator MIF in the control of insulin secretion during stress
Waeber G, Calandra T, Bonny C, Bucala R. A role for the endocrine and pro‐inflammatory mediator MIF in the control of insulin secretion during stress. Diabetes/Metabolism Research And Reviews 1999, 15: 47-54. PMID: 10398546, DOI: 10.1002/(sici)1520-7560(199901/02)15:1<47::aid-dmrr9>3.0.co;2-j.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorInsulin secretionMediator macrophage migration inhibitory factorSystemic inflammatory processSystemic inflammatory responseMigration inhibitory factorAnterior pituitary glandMIF levelsAdrenal axisInsulin resistanceGlucocorticoid effectsImmune cellsInflammatory processInflammatory responseInflammatory systemPeripheral tissuesGlucose homeostasisInsulin releaseHost immunityUtilization of glucosePituitary glandInhibitory factorAutocrine factorSystemic responseDisease states
1997
Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor
Waeber G, Calandra T, Roduit R, Haefliger J, Bonny C, Thompson N, Thorens B, Temler E, Meinhardt A, Bacher M, Metz C, Nicod P, Bucala R. Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 4782-4787. PMID: 9114069, PMCID: PMC20802, DOI: 10.1073/pnas.94.9.4782.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInsulin releaseInsulin secretionBeta cellsRecombinant macrophage migration inhibitory factorInhibitory factorGlucose-induced insulin releasePancreatic islet beta cellsInsulin-secreting beta cellsINS-1 cell lineIslet beta cellsIsolated rat isletsInsulin secretion responseIslets of LangerhansConcentration-dependent mannerIslet cell productsImmune cellsT lymphocytesPituitary hormonesPerifusion studiesAutocrine fashionRat isletsSecretion responseGlucocorticoid stimulation