2002
Identification of a minimal peptide sequence of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties
Kapurniotu A, Bernhagen J, Fischle W, Teichberg S, Voelter W, Bucala R. Identification of a minimal peptide sequence of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties. American Peptide Symposia 2002, 5: 394-395. DOI: 10.1007/0-306-46862-x_167.Peer-Reviewed Original ResearchIslet amyloid polypeptide
1998
Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide
Kapurniotu A, Bernhagen J, Greenfield N, Al‐Abed Y, Teichberg S, Frank R, Voelter W, Bucala R. Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide. The FEBS Journal 1998, 251: 208-216. PMID: 9492286, DOI: 10.1046/j.1432-1327.1998.2510208.x.Peer-Reviewed Original ResearchConceptsAmyloid formationIslet amyloid polypeptidePre-formed aggregatesAdvanced glycosylation end productsIAPP amyloid formationAlzheimer's disease amyloid peptideCircular dichroism spectropolarimetryNucleation-dependent polymerization mechanismBeta-sheet conformationIAPP aggregationBiophysical techniquesIAPP aggregatesHigh molecular massFormation of amyloidAmyloid structuresGreen-gold birefringenceProtein amino groupsCharacteristic fibrillar structureIslet amyloid formationSeedsFibrillar amyloid structuresGlycosylationPolymerization mechanismNon-enzymatic additionPeptide aggregation