2000
De Novo Expression of Macrophage Migration Inhibitory Factor in Atherogenesis in Rabbits
Lin S, Yu X, Chen Y, Huang X, Metz C, Bucala R, Lau C, Lan H. De Novo Expression of Macrophage Migration Inhibitory Factor in Atherogenesis in Rabbits. Circulation Research 2000, 87: 1202-1208. PMID: 11110779, DOI: 10.1161/01.res.87.12.1202.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorUpregulation of MIFSmooth muscle cellsVascular endothelial cellsMIF expressionMigration inhibitory factorFatty streak lesion formationInhibitory factorAbility of MIFIntercellular adhesion molecule-1 expressionAdhesion molecule-1 expressionFoam cell-rich lesionsNew Zealand white rabbitsAccumulation of macrophagesMolecule-1 expressionTranscriptase-polymerase chain reactionHypercholesterolemic rabbit modelEarly fatty streaksZealand white rabbitsDe novo expressionMacrophage-mediated diseasesMIF levelsCholesterol dietMIF mRNANormal dietInvolvement of Macrophage Migration Inhibitory Factor (MIF) in Experimental Uric Acid Nephropathy
Kim Y, Huang X, Suga S, Mazzali M, Tang D, Metz C, Bucala R, Kivlighn S, Johnson R, Lan H. Involvement of Macrophage Migration Inhibitory Factor (MIF) in Experimental Uric Acid Nephropathy. Molecular Medicine 2000, 6: 837-848. PMID: 11126199, PMCID: PMC1949919, DOI: 10.1007/bf03401822.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorUric acid crystal depositionMigration inhibitory factorUric acid nephropathyGranuloma formationMIF mRNAMIF proteinOxonic acidInhibitory factorCrystal depositionAcute uric acid nephropathyAreas of granulomasMIF mRNA expressionProgressive tubulointerstitial injuryRoutine light microscopyUrate nephropathyWestern blot analysisMIF expressionLocal cellular responseMIF secretionTubulointerstitial damageTubulointerstitial injuryInterleukin-2RRenal diseaseDTH reactionExpression of macrophage migration inhibitory factor in human glomerulonephritis
Lan H, Yang N, Nikolic-Paterson D, Yu X, Mu W, Isbel N, Metz C, Bucala R, Atkins R. Expression of macrophage migration inhibitory factor in human glomerulonephritis. Kidney International 2000, 57: 499-509. PMID: 10652026, DOI: 10.1046/j.1523-1755.2000.00869.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBiopsyCohort StudiesEpithelial CellsFemaleGene ExpressionGlomerulonephritis, MembranoproliferativeGlomerulonephritis, MembranousHumansIn Situ HybridizationKidney GlomerulusMacrophage Migration-Inhibitory FactorsMacrophagesMaleMiddle AgedReference ValuesRNA, MessengerT-LymphocytesConceptsMacrophage migration inhibitory factorMIF expressionMigration inhibitory factorFocal segmental glomerulosclerosisHuman glomerulonephritisProliferative formsMIF mRNAPathogenic roleExperimental glomerulonephritisInhibitory factorProgressive formRenal MIF expressionRenal function impairmentT cell accumulationT-cell infiltratesEpithelial cellsMinimal change diseaseFocal segmental lesionsGlomerular endothelial cellsTubular epithelial cellsNormal human kidneyAttractive therapeutic targetCreatinine clearanceGlomerular epithelial cellsLupus nephritis
1998
MIF Expression in the Rat Brain: Implications for Neuronal Function
Bacher M, Meinhardt A, Lan H, Dhabhar F, Mu W, Metz C, Chesney J, Gemsa D, Donnelly T, Atkins R, Bucala R. MIF Expression in the Rat Brain: Implications for Neuronal Function. Molecular Medicine 1998, 4: 217-230. PMID: 9606175, PMCID: PMC2230367, DOI: 10.1007/bf03401919.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF mRNA expressionMIF expressionMIF mRNAMIF immunoreactivityMIF proteinGlucocorticoid actionRecombinant macrophage migration inhibitory factorNeuroendocrine systemMRNA expressionSystemic inflammatory responseInflammatory stress responseMigration inhibitory factorCerebrospinal fluid contentAnterior pituitary glandMonocytes/macrophagesTNF-α proteinHippocampal CA3 fieldTotal brain RNAProinflammatory factorsMIF antibodySitu hybridizationIntracisternal injectionBaseline expression patternCytokine production