1998
Filarial Nematode Parasites Secrete a Homologue of the Human Cytokine Macrophage Migration Inhibitory Factor
Pastrana D, Raghavan N, FitzGerald P, Eisinger S, Metz C, Bucala R, Schleimer R, Bickel C, Scott A. Filarial Nematode Parasites Secrete a Homologue of the Human Cytokine Macrophage Migration Inhibitory Factor. Infection And Immunity 1998, 66: 5955-5963. PMID: 9826378, PMCID: PMC108754, DOI: 10.1128/iai.66.12.5955-5963.1998.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorCytokine macrophage migration inhibitory factorMonocytes/macrophagesMigration inhibitory factorHuman monocytes/macrophagesExcretory-secretory productsInhibitory factorProinflammatory cytokine macrophage migration inhibitory factorParasite excretory-secretory productsMurine macrophage migration inhibitory factorLong-term chronic infectionsMonocyte/macrophage migrationHost immune responseHuman macrophage migration inhibitory factorFilarial nematode parasitesTh2 responsesTh2 biasAntiparasite immunityChronic infectionImmunological environmentFilarial antigenImmune responseUterine wallCytokine homologuesMacrophage migration
1996
Macrophage migration inhibitory factor production by Leydig cells: evidence for a role in the regulation of testicular function
Meinhardt A, Bacher M, McFarlane J, Metz C, Seitz J, Hedger M, de Kretser D, Bucala R. Macrophage migration inhibitory factor production by Leydig cells: evidence for a role in the regulation of testicular function. Endocrinology 1996, 137: 5090-5095. DOI: 10.1210/en.137.11.5090.Peer-Reviewed Original ResearchLeydig cellsMacrophage migration inhibitory factorSeminiferous tubulesRat testisHeads of elongated spermatidsRegulation of testicular functionAdult rat seminiferous tubulesTM3 Leydig cell lineTesticular functionLeydig cell steroidogenesis in vitroPeritubular myoid cellsLeydig cell lineAdult rat testisRat seminiferous tubulesPurified Leydig cellsMIF messenger RNAExpression of MIF messenger RNAMessenger RNALong-term hypophysectomized ratsIntracellular macrophage migration inhibitory factorMigration inhibitory factor productionProduct of activated T lymphocytesMurine macrophage migration inhibitory factorElongated spermatidsMacrophage migration inhibitory factor production