1996
Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗)
Al-Abed Y, Bucala R, Liebich H, Voelter W. Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗). Journal Of Biological Chemistry 1996, 271: 2892-2896. PMID: 8621676, DOI: 10.1074/jbc.271.6.2892.Peer-Reviewed Original ResearchConceptsChemical ionization mass spectroscopyGas chromatography-mass spectrometry analysisIonization mass spectroscopyChromatography-mass spectrometry analysisOxidation product 4Acid side chainsUnsaturated fatty acyl groupsTransition metalsFatty acid side chainsHead groupsMass spectroscopySide chainsProduct 4Chemical basisCovalent additionFatty acyl groupsFree radical generating systemOxidationRadical generating systemSpectrometry analysisAcyl groupsMajor compoundsTissue LDL receptorsHigh affinityOxidative modification
1995
Advanced Glycosylation Endproducts in Diabetic Renal Disease: Clinical Measurement, Pathophysiological Significance, and Prospects for Pharmacological Inhibition
Bucala R, Vlassara H. Advanced Glycosylation Endproducts in Diabetic Renal Disease: Clinical Measurement, Pathophysiological Significance, and Prospects for Pharmacological Inhibition. Blood Purification 1995, 13: 160-170. PMID: 7619388, DOI: 10.1159/000170199.Peer-Reviewed Original ResearchConceptsAdvanced glycosylation endproductsDiabetic renal diseaseNormal renal functionInactivate nitric oxideSpecific therapeutic modalitiesTissue LDL receptorsForms of LDLRenal functionRenal diseaseLDL levelsTherapeutic modalitiesVascular permeabilityPathophysiological significanceAdvanced glycosylationLipoprotein depositionPharmacological inhibitionLDL receptorClinical measurementsNitric oxideEndothelial cellsMarked increaseMiddle moleculesLDLToxic effectsEndproducts