2021
MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model
Tilstam PV, Schulte W, Holowka T, Kim BS, Nouws J, Sauler M, Piecychna M, Pantouris G, Lolis E, Leng L, Bernhagen J, Fingerle-Rowson G, Bucala R. MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model. Journal Of Clinical Investigation 2021, 131: e127171. PMID: 34850744, PMCID: PMC8631602, DOI: 10.1172/jci127171.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytokinesDisease Models, AnimalFemaleFlow CytometryGene Expression ProfilingInflammationIntramolecular OxidoreductasesLeukocyte CountMacrophage Migration-Inhibitory FactorsMacrophagesMacrophages, PeritonealMaleMiceMice, Inbred C57BLMice, TransgenicPeritoneal LavagePhenotypeProtein BindingRNA-SeqSepsisSignal TransductionConceptsMacrophage migration inhibitory factorSmall peritoneal macrophagesLarge peritoneal macrophagesPolymicrobial sepsisPeritoneal macrophagesMIF receptor CD74MIF promoter polymorphismsMIF-2Migration inhibitory factorPolymicrobial sepsis modelMIF deficiencyAdoptive transferSeptic shockSurvival benefitInfectious insultsMIF antibodyExcessive inflammationInflammatory cytokinesReceptor CD74Sepsis modelProtective effectPeritoneal cavityDifferent infectionsPromoter polymorphismInflammatory macrophages
1998
Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria
Calandra T, Spiegel L, Metz C, Bucala R. Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11383-11388. PMID: 9736745, PMCID: PMC21651, DOI: 10.1073/pnas.95.19.11383.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBacterial ToxinsCell DivisionCells, CulturedDisease Models, AnimalEnterotoxinsExotoxinsGram-Positive BacteriaInflammationInterferon-gammaInterleukin-2Lymphocyte ActivationMacrophage Migration-Inhibitory FactorsMacrophages, PeritonealMicePituitary GlandShock, SepticSpleenStaphylococcusStreptococcusSuperantigensConceptsMacrophage migration inhibitory factorMigration inhibitory factorMIF secretionInhibitory factorStaphylococcal toxic shock syndrome toxin 1Toxic shock syndrome toxin-1Anti-MIF antibodiesSplenocyte cytokine productionTSST-1 injectionInterferon-gamma secretionLethal mouse modelStreptococcal pyrogenic exotoxinT cell cytokinesInnate host responseLethal toxic shockProliferation of splenocytesT-cell productsInnate immune responseSyndrome toxin-1Dose-response studyMouse peritoneal macrophagesSpleen enlargementMIF antibodyC57BL/6 miceCytokine production