1999
Peripheral blood fibrocytes with foamy virus infection-like morphology
Grab D, Lanners H, Williams W, Bucala R. Peripheral blood fibrocytes with foamy virus infection-like morphology. Human Pathology 1999, 30: 1395-1396. PMID: 10571524, DOI: 10.1016/s0046-8177(99)90076-x.Peer-Reviewed Original ResearchInteraction of Borrelia burgdorferi with Peripheral Blood Fibrocytes, Antigen-Presenting Cells with the Potential for Connective Tissue Targeting
Grab D, Lanners H, Martin L, Chesney J, Cai C, Adkisson H, Bucala R. Interaction of Borrelia burgdorferi with Peripheral Blood Fibrocytes, Antigen-Presenting Cells with the Potential for Connective Tissue Targeting. Molecular Medicine 1999, 5: 46-54. PMID: 10072447, PMCID: PMC2230375, DOI: 10.1007/bf03402138.Peer-Reviewed Original ResearchConceptsPeripheral blood fibrocytesBlood fibrocytesDifferent cell typesB. burgdorferiB. burgdorferi bindsInteraction of BorreliaMolecular mechanismsOspB proteinsAntigen presenting cellsCell typesFibroblast-like cellsCellular interactionsCell membraneJoint connective tissuesCollagen type ILyme arthritisPresent antigensInflammatory processT cellsFunctional capacityCellular collagenImmune systemFlow cytometryFibrocytesConnective tissue
1998
Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide
Kapurniotu A, Bernhagen J, Greenfield N, Al‐Abed Y, Teichberg S, Frank R, Voelter W, Bucala R. Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide. The FEBS Journal 1998, 251: 208-216. PMID: 9492286, DOI: 10.1046/j.1432-1327.1998.2510208.x.Peer-Reviewed Original ResearchConceptsAmyloid formationIslet amyloid polypeptidePre-formed aggregatesAdvanced glycosylation end productsIAPP amyloid formationAlzheimer's disease amyloid peptideCircular dichroism spectropolarimetryNucleation-dependent polymerization mechanismBeta-sheet conformationIAPP aggregationBiophysical techniquesIAPP aggregatesHigh molecular massFormation of amyloidAmyloid structuresGreen-gold birefringenceProtein amino groupsCharacteristic fibrillar structureIslet amyloid formationSeedsFibrillar amyloid structuresGlycosylationPolymerization mechanismNon-enzymatic additionPeptide aggregation
1994
Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
Bucala R, Spiegel L, Chesney J, Hogan M, Cerami A. Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair. Molecular Medicine 1994, 1: 71-81. PMID: 8790603, PMCID: PMC2229929, DOI: 10.1007/bf03403533.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBone MarrowBone Marrow CellsCD4 AntigensCell AdhesionCells, CulturedCentrifugationChimeraCollagenConnective TissueCytoskeletonDNA-Binding ProteinsDose-Response Relationship, RadiationFemaleFibroblastsFlow CytometryFluorescent Antibody TechniqueHumansImmunohistochemistryLeukocytesMaleMiceMice, Inbred BALB CMicroscopy, ElectronMolecular Sequence DataNuclear ProteinsPhenotypeSex-Determining Region Y ProteinTime FactorsTranscription FactorsTransplantation, HeterologousVimentinWound HealingConceptsTissue injuryLeukocyte subpopulationsScar formationLong-term remodelingFibroblast-like propertiesNormal wound repairConnective tissue scarConnective tissue elementsCell typesFibrotic responseTissue scarWound chambersPathological fibrotic responsesHost responseInjuryConnective tissueFibrocytesWound repairFibroblast propertiesTissue repairTissue elementsDistinctive phenotypeSubpopulationsTissueNovel cell types
1985
Glucocorticoid-lens protein adducts in experimentally induced steroid cataracts
Bucala R, Callati M, Manabe S, Cotlier E, Cerami A. Glucocorticoid-lens protein adducts in experimentally induced steroid cataracts. Experimental Eye Research 1985, 40: 853-863. PMID: 4018168, DOI: 10.1016/0014-4835(85)90130-7.Peer-Reviewed Original Research