2023
Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine
Rosell D, Slifstein M, Thompson J, Xu X, Perez-Rodriguez M, McClure M, Hazlett E, New A, Nabulsi N, Huang Y, Carson R, Siever L, Abi-Dargham A, Koenigsberg H. Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine. Psychopharmacology 2023, 240: 361-371. PMID: 36640190, DOI: 10.1007/s00213-022-06306-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexAnti-aggressive effectsIED patientsPositron emission tomographyVentral striatumTransporter availabilityChildhood traumaSerotonin transporter availabilityRational treatment selectionIntermittent explosive disorderFluoxetine 20Fluoxetine treatmentSerotonergic abnormalitiesHealthy comparison participantsTreatment selectionRisk individualsObjectivesThe aimPatientsCingulate cortexExplosive disorderEmission tomographyImpulsive aggressionNovel therapeuticsFluoxetineNeuroanatomical basis
2020
Multimodal investigation of dopamine D2/D3 receptors, default mode network suppression, and cognitive control in cocaine-use disorder
Worhunsky PD, Angarita GA, Zhai ZW, Matuskey D, Gallezot JD, Malison RT, Carson RE, Potenza MN. Multimodal investigation of dopamine D2/D3 receptors, default mode network suppression, and cognitive control in cocaine-use disorder. Neuropsychopharmacology 2020, 46: 316-324. PMID: 33007778, PMCID: PMC7852666, DOI: 10.1038/s41386-020-00874-7.Peer-Reviewed Original ResearchConceptsCocaine use disorderDMN suppressionDefault mode networkCognitive controlExecutive functioningStroop performanceCognitive control processesHealthy comparison participantsModerated-mediation analysisImproved task performanceStroop taskStimulant use disorderCognitive performanceTask performanceComparison participantsAddicted populationMode networkNetwork suppressionFMRI dataCUD participantsHC individualsMultimodal investigationControl processIndirect effectsD2R levels