2016
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging
Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J. Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging. ACS Nano 2016, 10: 4209-4218. PMID: 26967254, PMCID: PMC5257033, DOI: 10.1021/acsnano.5b07573.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBiological TransportBlood-Brain BarrierBrain NeoplasmsCell Line, TumorDecanoic AcidsDrug Delivery SystemsEthanolaminesFemaleGenetic TherapyHeterograftsHumansMatrix Metalloproteinase 2MiceMice, Inbred C57BLNanoparticlesOptical ImagingPaclitaxelPermeabilityPolymersPurinesPyrazolesScorpion VenomsTranscytosisTumor MicroenvironmentConceptsBlood-brain barrierLow delivery efficiencyTransport of nanoparticlesCancer gene therapyNanoparticle deliveryMore nanoparticlesBrain tumorsNanoparticlesDelivery efficiencyGene therapySystemic deliveryNPsBrain malignanciesBBB modulatorsPharmacological agentsBrain cancerBrain regionsTumorsDeliveryBrainImproved treatmentInadequate amountsPositive feedback loopChemotherapyMalignancy
2013
MO‐D‐141‐01: Quantification of Tumor Hypoxia Using [18F]‐Fluoromisonidazole Positron Emission Tomography and Tracer Kinetic Modeling
Kelada O, Rockwell S, Carson R, Decker R, Oelfke U, Carlson D. MO‐D‐141‐01: Quantification of Tumor Hypoxia Using [18F]‐Fluoromisonidazole Positron Emission Tomography and Tracer Kinetic Modeling. Medical Physics 2013, 40: 399-399. DOI: 10.1118/1.4815248.Peer-Reviewed Original ResearchPositron emission tomographyBlood ratioComputed tomographyFluoromisonidazole positron emission tomographyMale BALB/c miceEmission tomographyTumor hypoxiaBALB/c miceEMT-6 tumorsNon-invasive imaging methodVoxel basisTreatment failureC miceConventional tumorHypoxia quantificationHypoxic fractionAnaesthetized animalsTumorsHistologic sectionsPharmacokinetic modelPharmacokinetic modelingDynamic positron emission tomographyPET imagingHypoxic radioresistanceBetter delineation