2020
Inverse changes in raphe and cortical 5‐HT1B receptor availability after acute tryptophan depletion in healthy human subjects
Baldassarri SR, Park E, Finnema SJ, Planeta B, Nabulsi N, Najafzadeh S, Ropchan J, Huang Y, Hannestad J, Maloney K, Bhagwagar Z, Carson RE. Inverse changes in raphe and cortical 5‐HT1B receptor availability after acute tryptophan depletion in healthy human subjects. Synapse 2020, 74: e22159. PMID: 32324935, PMCID: PMC7426238, DOI: 10.1002/syn.22159.Peer-Reviewed Original Research
2000
The Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled Tracer
Shoaf S, Carson R, Hommer D, Williams W, Higley J, Schmall B, Herscovitch P, Eckelman W, Linnoila M. The Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled Tracer. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 244-252. PMID: 10698060, DOI: 10.1097/00004647-200002000-00004.Peer-Reviewed Original ResearchConceptsPositron emission tomographySerotonin synthesisOverdose of phenobarbitalBrain serotonin synthesis rateIsoflurane-anesthetized rhesus monkeysSerotonin synthesis rateBrain concentrationsSecond doseBrain samplesEmission tomographyRhesus monkeysDual administrationTryptophan uptakePatlak plotSerotoninMinimal conversionAdministrationMonkeysSynthesis rateL-tryptophanPET imagesPET dataTotal countOverdoseExternal quantification