2023
Reductions in synaptic marker SV2A in early-course Schizophrenia
Yoon J, Zhang Z, Mormino E, Davidzon G, Minzenberg M, Ballon J, Kalinowski A, Hardy K, Naganawa M, Carson R, Khalighi M, Park J, Levinson D, Chin F. Reductions in synaptic marker SV2A in early-course Schizophrenia. Journal Of Psychiatric Research 2023, 161: 213-217. PMID: 36934603, DOI: 10.1016/j.jpsychires.2023.02.026.Peer-Reviewed Original ResearchConceptsChronic patientsSynaptic pruningStage of illnessEarly course patientsEarly course schizophreniaSeverity of delusionsWidespread reductionMajor disease mechanismsSynaptic deficitsSynaptic markersSynaptic eliminationPET scansFormal onsetBrain regionsSignificant positive correlationPatientsSchizophrenia studiesSchizophreniaDisease mechanismsCognitive performanceIllnessEarly phaseSpecific bindingPresent studyPositive correlation
1995
Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study
Berman K, Ostrem J, Randolph C, Gold J, Goldberg T, Coppola R, Carson R, Herscovitch P, Weinberger D. Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study. Neuropsychologia 1995, 33: 1027-1046. PMID: 8524452, DOI: 10.1016/0028-3932(95)00035-2.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TestDorsolateral prefrontal cortexCard Sorting TestSorting TestSensorimotor control taskPhysiological activationInferior parietal lobuleInferior temporal cortexCognitive operationsPrefrontal lesionsMemory componentsNeuropsychological testsVisual associationParietal lobulePositron emission tomographyPrefrontal cortexNeural circuitryControl taskCortical networksTemporal cortexWCST activationExperiential phenomenaFrontal cortexPositron emission tomography studyRegional cerebral blood flow