2022
IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
Zhang X, Luo S, Wang M, Huang Q, Fang W, Li J, Liu T, Zhang Y, Deng Z, Liu CL, Guan S, Ayala JE, Flavell RA, Kulkarni RN, Libby P, Guo J, Liu Z, Shi GP. IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. Developmental Cell 2022, 57: 1496-1511.e6. PMID: 35675813, PMCID: PMC9233156, DOI: 10.1016/j.devcel.2022.05.013.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1Β-cell proliferationInsulin secretionΒ-cellsMacrophage expansionDiet-induced glucose intoleranceCell apoptosisIslet β-cell functionAcinar cellsCell proliferationΒ-cell functionIslet α-cellsCell developmentIL18 receptorΒ-cell apoptosisΒ-cell developmentDiabetic patientsGlucose intoleranceGlucose toleranceMacrophage accumulationInsulin sensitivityGLP1 receptorIslet sizePeptide-1Mouse pancreases
2001
Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary*
Matikainen T, Perez G, Zheng T, Kluzak T, Rueda B, Flavell R, Tilly J. Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary*. Endocrinology 2001, 142: 2468-2480. DOI: 10.1210/en.142.6.2468.Peer-Reviewed Original ResearchProgrammed cell deathCaspase-3Involvement of caspase-3Absence of caspase-3Programmed cell death signalingDNA cleavageGranulosa cellsCaspase-3 deficiencyAnalysis of DNA cleavageCell apoptosisGerm cell apoptosisInternucleosomal DNA cleavageCell death signalingCultures of wild-typeGranulosa cell demiseCell lineage specificationOccurrence of apoptosisAntral folliclesApoptosis executionWild-type granulosa cellsDeath signalingChromatin condensationDevelopmental cuesGranulosa cell apoptosisCell demise