2022
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells
Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W, Flavell RA, Li HB. RNA m6A demethylase ALKBH5 regulates the development of γδ T cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2203318119. PMID: 35939687, PMCID: PMC9388086, DOI: 10.1073/pnas.2203318119.Peer-Reviewed Original ResearchConceptsDemethylase ALKBH5Messenger RNAΓδ T cellsΓδ T cell biologyCommon posttranscriptional modificationΓδ T cell developmentT cell biologyT cell developmentCell precursorsT cell precursorsMammalian cellsRNA modificationsPosttranscriptional modificationsTissue homeostasisCell biologyT cellsTarget genesCheckpoint roleCell developmentM6A demethylase ALKBH5ALKBH5Γδ T-cell originΓδ T cell repertoireCell populationsEarly development
2010
Human Thrombopoietin Knockin Mice Efficiently Support Human Hematopoiesis In Vivo
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Eynon E, Stevens S, Manz M, Flavell R. Human Thrombopoietin Knockin Mice Efficiently Support Human Hematopoiesis In Vivo. Blood 2010, 116: 403. DOI: 10.1182/blood.v116.21.403.403.Peer-Reviewed Original ResearchHematopoietic stem cellsHuman hematopoietic stemHematopoietic stemSelf-renewal capacityHuman hematopoiesisHuman cellsMultilineage differentiationHematopoietic cellsField of hematopoiesisLong-term hematopoietic stem cellsHuman CD34Progenitor cell biologyStem cellsProgenitor cellsHuman hematopoietic cellsHuman hematopoietic stem cellsHuman thrombopoietinHuman homologuePopulation of cellsCell biologyEnhanced self-renewal capacityFunctional analysisSecondary recipientsLymphoid lineageXenogeneic environment