2014
ΜΙSΤRG Mice Support Good-Risk AML Engraftment
Ellegast J, Saito Y, Flavell R, Manz M. ΜΙSΤRG Mice Support Good-Risk AML Engraftment. Blood 2014, 124: 3808. DOI: 10.1182/blood.v124.21.3808.3808.Peer-Reviewed Original ResearchGood-risk acute myeloid leukemiaRisk acute myeloid leukemiaAcute myeloid leukemiaAML engraftmentMISTRG miceEngraftment levelsNSG miceTherapeutic strategiesAML samplesGM-CSFAggressive acute myeloid leukemiaM-CSFHuman AML samplesBone marrow aspirationPeripheral blood analysisAggressiveness of diseaseBone marrow analysisGenetic alterationsExtent of engraftmentUnsatisfactory treatment optionsNovel therapeutic strategiesDirect therapeutic strategiesPreliminary data pointAML presentationCD19 depletion
2010
Human Interleukin-3/Granulocyte Macrophage-Colony Stimulating Factor Knock-In Mice Support Human Myeloid Cell Reconstitution and Human Immune Responses In the Lung.
Willinger T, Rongvaux A, Takizawa H, Eynon E, Stevens S, Manz M, Flavell R. Human Interleukin-3/Granulocyte Macrophage-Colony Stimulating Factor Knock-In Mice Support Human Myeloid Cell Reconstitution and Human Immune Responses In the Lung. Blood 2010, 116: 3789. DOI: 10.1182/blood.v116.21.3789.3789.Peer-Reviewed Original ResearchHuman immune responsePulmonary alveolar proteinosisImmune responseHuman myeloid cellsKI miceCell reconstitutionMyeloid cellsEnhanced systemic inflammatory responseFunctional human immune systemGM-CSFStrong innate immune responseSystemic inflammatory responseInfluenza virus infectionIL-3Human immune cellsInnate immune responseNew mouse modelHuman alveolar macrophagesHuman immune systemGranulocyte-macrophage colonyPAP syndromeHumanized miceAlveolar proteinosisImmune cellsInflammatory response