Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary*
Matikainen T, Perez G, Zheng T, Kluzak T, Rueda B, Flavell R, Tilly J. Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary*. Endocrinology 2001, 142: 2468-2480. DOI: 10.1210/en.142.6.2468.Peer-Reviewed Original ResearchProgrammed cell deathCaspase-3Involvement of caspase-3Absence of caspase-3Programmed cell death signalingDNA cleavageGranulosa cellsCaspase-3 deficiencyAnalysis of DNA cleavageCell apoptosisGerm cell apoptosisInternucleosomal DNA cleavageCell death signalingCultures of wild-typeGranulosa cell demiseCell lineage specificationOccurrence of apoptosisAntral folliclesApoptosis executionWild-type granulosa cellsDeath signalingChromatin condensationDevelopmental cuesGranulosa cell apoptosisCell demise