Humanized Mouse Model of Myeloma Reveals Clinically Occult Genomic Changes in Primary Tumor Cells
Verma R, Strowig T, Das R, Koduru S, Hafemann A, Hopf S, Kocoglu M, Borsotti C, Zhang L, Branagan A, Eynon E, Manz M, Flavell R, Dhodapkar M. Humanized Mouse Model of Myeloma Reveals Clinically Occult Genomic Changes in Primary Tumor Cells. Blood 2015, 126: 22. DOI: 10.1182/blood.v126.23.22.22.Peer-Reviewed Original ResearchPrimary tumor cellsTumor cellsWhole-exome sequencingCopy number alterationsReliable engraftmentPrimary MM tumor cellsIndividual miceHuman tumorsGrowth factorImmune rejection mechanismsHigh-risk MMHumanized mouse modelEvaluation of tumorsMM tumor cellsPrimary human tumor cellsCytokines/growth factorsSame tumor cellsPlasma cell neoplasiaBaseline tumorMM patientsMyeloma patientsInitial tumorPatterns of LOHHuman MMPlasma cells