2022
Human neutrophil development and functionality are enabled in a humanized mouse model
Zheng Y, Sefik E, Astle J, Karatepe K, Öz HH, Solis AG, Jackson R, Luo HR, Bruscia EM, Halene S, Shan L, Flavell RA. Human neutrophil development and functionality are enabled in a humanized mouse model. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2121077119. PMID: 36269862, PMCID: PMC9618085, DOI: 10.1073/pnas.2121077119.Peer-Reviewed Original ResearchConceptsHumanized mouse modelMouse modelHuman immune systemHuman neutrophilsImmune systemFunctional human immune systemGranulocyte colony-stimulating factorUnique mouse modelColony-stimulating factorHuman G-CSFMISTRG miceG-CSF receptor geneBacterial burdenInfectious challengeG-CSFNeutrophilsMiceNeutrophil developmentReceptor geneDisease
2015
Humanized Mouse Model of Myeloma Reveals Clinically Occult Genomic Changes in Primary Tumor Cells
Verma R, Strowig T, Das R, Koduru S, Hafemann A, Hopf S, Kocoglu M, Borsotti C, Zhang L, Branagan A, Eynon E, Manz M, Flavell R, Dhodapkar M. Humanized Mouse Model of Myeloma Reveals Clinically Occult Genomic Changes in Primary Tumor Cells. Blood 2015, 126: 22. DOI: 10.1182/blood.v126.23.22.22.Peer-Reviewed Original ResearchPrimary tumor cellsTumor cellsWhole-exome sequencingCopy number alterationsReliable engraftmentPrimary MM tumor cellsIndividual miceHuman tumorsGrowth factorImmune rejection mechanismsHigh-risk MMHumanized mouse modelEvaluation of tumorsMM tumor cellsPrimary human tumor cellsCytokines/growth factorsSame tumor cellsPlasma cell neoplasiaBaseline tumorMM patientsMyeloma patientsInitial tumorPatterns of LOHHuman MMPlasma cells
2014
Development and function of human innate immune cells in a humanized mouse model
Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA. Development and function of human innate immune cells in a humanized mouse model. Nature Biotechnology 2014, 32: 364-372. PMID: 24633240, PMCID: PMC4017589, DOI: 10.1038/nbt.2858.Peer-Reviewed Original Research
2012
Humanized mouse models of infectious diseases
Strowig T, Flavell R. Humanized mouse models of infectious diseases. Drug Discovery Today Disease Models 2012, 9: e11-e16. DOI: 10.1016/j.ddmod.2011.10.004.Peer-Reviewed Original Research