2013
Inflammasomes and Mucosal Immune Response
Elinav E, Henao-Mejia J, Flavell R. Inflammasomes and Mucosal Immune Response. Else Kröner-Fresenius Symposia 2013, 4: 48-52. DOI: 10.1159/000346510.Peer-Reviewed Original ResearchProtein complexesImmune responseDamage signalsCritical regulatorMolecular characterizationContext of infectionInnate immune responseCell deathMucosal immune responsesMicrobial infectionsPotent inflammatory cytokineCaspase-1Direct activationInflammatory cytokinesSterile inflammationMetabolic disordersInflammasome resultsDiverse rangeInflammasomeKey componentRegulatorInfectionProteinNLRC4AIM2
2010
Human Interleukin-3/Granulocyte Macrophage-Colony Stimulating Factor Knock-In Mice Support Human Myeloid Cell Reconstitution and Human Immune Responses In the Lung.
Willinger T, Rongvaux A, Takizawa H, Eynon E, Stevens S, Manz M, Flavell R. Human Interleukin-3/Granulocyte Macrophage-Colony Stimulating Factor Knock-In Mice Support Human Myeloid Cell Reconstitution and Human Immune Responses In the Lung. Blood 2010, 116: 3789. DOI: 10.1182/blood.v116.21.3789.3789.Peer-Reviewed Original ResearchHuman immune responsePulmonary alveolar proteinosisImmune responseHuman myeloid cellsKI miceCell reconstitutionMyeloid cellsEnhanced systemic inflammatory responseFunctional human immune systemGM-CSFStrong innate immune responseSystemic inflammatory responseInfluenza virus infectionIL-3Human immune cellsInnate immune responseNew mouse modelHuman alveolar macrophagesHuman immune systemGranulocyte-macrophage colonyPAP syndromeHumanized miceAlveolar proteinosisImmune cellsInflammatory response