2022
Human neutrophil development and functionality are enabled in a humanized mouse model
Zheng Y, Sefik E, Astle J, Karatepe K, Öz HH, Solis AG, Jackson R, Luo HR, Bruscia EM, Halene S, Shan L, Flavell RA. Human neutrophil development and functionality are enabled in a humanized mouse model. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2121077119. PMID: 36269862, PMCID: PMC9618085, DOI: 10.1073/pnas.2121077119.Peer-Reviewed Original ResearchConceptsHumanized mouse modelMouse modelHuman immune systemHuman neutrophilsImmune systemFunctional human immune systemGranulocyte colony-stimulating factorUnique mouse modelColony-stimulating factorHuman G-CSFMISTRG miceG-CSF receptor geneBacterial burdenInfectious challengeG-CSFNeutrophilsMiceNeutrophil developmentReceptor geneDisease
2014
ΜΙSΤRG Mice Support Good-Risk AML Engraftment
Ellegast J, Saito Y, Flavell R, Manz M. ΜΙSΤRG Mice Support Good-Risk AML Engraftment. Blood 2014, 124: 3808. DOI: 10.1182/blood.v124.21.3808.3808.Peer-Reviewed Original ResearchGood-risk acute myeloid leukemiaRisk acute myeloid leukemiaAcute myeloid leukemiaAML engraftmentMISTRG miceEngraftment levelsNSG miceTherapeutic strategiesAML samplesGM-CSFAggressive acute myeloid leukemiaM-CSFHuman AML samplesBone marrow aspirationPeripheral blood analysisAggressiveness of diseaseBone marrow analysisGenetic alterationsExtent of engraftmentUnsatisfactory treatment optionsNovel therapeutic strategiesDirect therapeutic strategiesPreliminary data pointAML presentationCD19 depletion