2002
Caspase-3 Is a Pivotal Mediator of Apoptosis during Regression of the Ovarian Corpus Luteum
Carambula S, Matikainen T, Lynch M, Flavell R, Gonçalves P, Tilly J, Rueda B. Caspase-3 Is a Pivotal Mediator of Apoptosis during Regression of the Ovarian Corpus Luteum. Endocrinology 2002, 143: 1495-1501. DOI: 10.1210/en.143.4.1495.Peer-Reviewed Original ResearchCaspase-3-deficient miceWT miceCorpora luteaCaspase-3Wild-typeLuteal regressionFemale littermatesCaspase-3 enzymePost-ovulationOvarian corpus luteumLevels of progesteroneRate of apoptosisEarly luteal phaseOccurrence of apoptosisAbsence of serumActivated caspase-3Detect activated caspase-3Ex vivo culture experimentsExogenous gonadotropinsNull miceMediators of apoptosisOrgan culture dishesIndividual CLCorpus luteumExecutioners of apoptosis
2001
Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary*
Matikainen T, Perez G, Zheng T, Kluzak T, Rueda B, Flavell R, Tilly J. Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary*. Endocrinology 2001, 142: 2468-2480. DOI: 10.1210/en.142.6.2468.Peer-Reviewed Original ResearchProgrammed cell deathCaspase-3Involvement of caspase-3Absence of caspase-3Programmed cell death signalingDNA cleavageGranulosa cellsCaspase-3 deficiencyAnalysis of DNA cleavageCell apoptosisGerm cell apoptosisInternucleosomal DNA cleavageCell death signalingCultures of wild-typeGranulosa cell demiseCell lineage specificationOccurrence of apoptosisAntral folliclesApoptosis executionWild-type granulosa cellsDeath signalingChromatin condensationDevelopmental cuesGranulosa cell apoptosisCell demise