Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice
Das R, Strowig T, Verma R, Koduru S, Hafemann A, Hopf S, Kocoglu M, Borsotti C, Zhang L, Branagan A, Eynon E, Manz M, Flavell R, Dhodapkar M. Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice. Blood 2015, 126: 120. DOI: 10.1182/blood.v126.23.120.120.Peer-Reviewed Original ResearchBone marrow mononuclear cellsMultiple myelomaMarrow mononuclear cellsPlasma cellsPlasma cell tumorsInterleukin-6Tumor cellsAsymptomatic MMHumanized miceMononuclear cellsCell tumorsFlow cytometryPathogenesis of MMAsymptomatic multiple myelomaExtra-medullary sitesSetting of patientsHuman MM cellsInnate immune cellsPlasma cell disordersPlasma cell leukemiaPlasma cell cloneImmune-deficient miceHuman plasma cell tumorsInnate immune cell developmentSingle-cell mass cytometryHumanized Mouse Model of Myeloma Reveals Clinically Occult Genomic Changes in Primary Tumor Cells
Verma R, Strowig T, Das R, Koduru S, Hafemann A, Hopf S, Kocoglu M, Borsotti C, Zhang L, Branagan A, Eynon E, Manz M, Flavell R, Dhodapkar M. Humanized Mouse Model of Myeloma Reveals Clinically Occult Genomic Changes in Primary Tumor Cells. Blood 2015, 126: 22. DOI: 10.1182/blood.v126.23.22.22.Peer-Reviewed Original ResearchPrimary tumor cellsTumor cellsWhole-exome sequencingCopy number alterationsReliable engraftmentPrimary MM tumor cellsIndividual miceHuman tumorsGrowth factorImmune rejection mechanismsHigh-risk MMHumanized mouse modelEvaluation of tumorsMM tumor cellsPrimary human tumor cellsCytokines/growth factorsSame tumor cellsPlasma cell neoplasiaBaseline tumorMM patientsMyeloma patientsInitial tumorPatterns of LOHHuman MMPlasma cells