2023
A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver
Ding C, Yu Z, Sefik E, Zhou J, Kaffe E, Wang G, Li B, Flavell R, Hu W, Ye Y, Li H. A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver. Nature Aging 2023, 3: 813-828. PMID: 37277640, DOI: 10.1038/s43587-023-00428-8.Peer-Reviewed Original ResearchConceptsAged miceLiver diseaseLiver microenvironmentAge-related liver diseasesYin Yang 1Liver immune microenvironmentRegulatory T cellsTreg-specific deletionPotential therapeutic targetMitochondrial functionYang 1Treg apoptosisTreg homeostasisTreg cellsTreg functionImmune microenvironmentLiver fibrosisMetabolic dysfunctionOptimal mitochondrial functionYoung miceT cellsLiver cancerTherapeutic targetAged liverLong noncoding RNA
2022
Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9
Fu Y, Pajulas A, Wang J, Zhou B, Cannon A, Cheung CCL, Zhang J, Zhou H, Fisher AJ, Omstead DT, Khan S, Han L, Renauld JC, Paczesny S, Gao H, Liu Y, Yang L, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Sun J, Bilgicer B, Sears CR, Yang K, Kaplan MH. Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. Nature Communications 2022, 13: 3811. PMID: 35778404, PMCID: PMC9249769, DOI: 10.1038/s41467-022-31596-7.Peer-Reviewed Original ResearchConceptsLung tumor growthIL-9Tumor growthAdoptive cell transfer therapyPulmonary interstitial macrophagesPotent anti-tumor activityLung cancer patientsCell transfer therapyLung tumor modelLung cancer therapyMultiple mouse modelsPotential therapeutic targetIL-9 signalingAnti-tumor activityPro-tumorigenic effectsAdoptive transferMacrophage axisPoor outcomePoor prognosisCancer patientsLung cancerArginase-1Interstitial macrophagesIL-9RInterstitial macrophage population