2022
IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
Zhang X, Luo S, Wang M, Huang Q, Fang W, Li J, Liu T, Zhang Y, Deng Z, Liu CL, Guan S, Ayala JE, Flavell RA, Kulkarni RN, Libby P, Guo J, Liu Z, Shi GP. IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. Developmental Cell 2022, 57: 1496-1511.e6. PMID: 35675813, PMCID: PMC9233156, DOI: 10.1016/j.devcel.2022.05.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGlucagon-Like Peptide 1HumansInsulinInsulin SecretionInsulin-Secreting CellsInterleukin-18MicePancreasConceptsGlucagon-like peptide-1Β-cell proliferationInsulin secretionΒ-cellsMacrophage expansionDiet-induced glucose intoleranceCell apoptosisIslet β-cell functionAcinar cellsCell proliferationΒ-cell functionIslet α-cellsCell developmentIL18 receptorΒ-cell apoptosisΒ-cell developmentDiabetic patientsGlucose intoleranceGlucose toleranceMacrophage accumulationInsulin sensitivityGLP1 receptorIslet sizePeptide-1Mouse pancreases
2011
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA. NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis. Cell 2011, 145: 745-757. PMID: 21565393, PMCID: PMC3140910, DOI: 10.1016/j.cell.2011.04.022.Peer-Reviewed Original ResearchConceptsDextran sodium sulfateDamage-associated molecular patternsIL-18 levelsInflammatory cell recruitmentInflammasome-deficient miceWild-type miceColonic microbial ecologyMouse colonic epithelial cellsColonic epithelial cellsColitogenic activityDSS colitisHuman IBDChemical colitisIL-18Antibiotic treatmentInflammasome pathwayNLRP6 inflammasomeCell recruitmentIntestinal hyperplasiaColitisCaspase-1Fecal microbiotaMolecular patternsEpithelial cellsExacerbation