2019
Transcriptional regulatory model of fibrosis progression in the human lung
McDonough JE, Ahangari F, Li Q, Jain S, Verleden SE, Herazo-Maya J, Vukmirovic M, DeIuliis G, Tzouvelekis A, Tanabe N, Chu F, Yan X, Verschakelen J, Homer RJ, Manatakis DV, Zhang J, Ding J, Maes K, De Sadeleer L, Vos R, Neyrinck A, Benos PV, Bar-Joseph Z, Tantin D, Hogg JC, Vanaudenaerde BM, Wuyts WA, Kaminski N. Transcriptional regulatory model of fibrosis progression in the human lung. JCI Insight 2019, 4 PMID: 31600171, PMCID: PMC6948862, DOI: 10.1172/jci.insight.131597.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAdvanced fibrosisAlveolar surface densityFibrosis progressionLung fibrosisHuman lungDynamic Regulatory Events MinerExtent of fibrosisIPF lungsPulmonary fibrosisControl lungsIPF tissueB lymphocytesFibrosisLungLinear mixed-effects modelsMixed-effects modelsGene expression changesSystems biology modelsDifferential gene expression analysisGene expression analysisProgressionGene expression networksRNA sequencingBiology models
2003
Pulmonary Expression of Leukemia Inhibitory Factor Induces B Cell Hyperplasia and Confers Protection in Hyperoxia*
Wang J, Chen Q, Corne J, Zhu Z, Lee CG, Bhandari V, Homer RJ, Elias JA. Pulmonary Expression of Leukemia Inhibitory Factor Induces B Cell Hyperplasia and Confers Protection in Hyperoxia*. Journal Of Biological Chemistry 2003, 278: 31226-31232. PMID: 12782633, DOI: 10.1074/jbc.m301820200.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorB-cell hyperplasiaCell hyperplasiaIL-6Protective effectTransgenic miceAlveolar-capillary protein leakB cell-mediated responsesInhibitory factorAdult respiratory distress syndromeHyperoxic acute lung injuryAcute lung injuryRespiratory distress syndromeCell-mediated responsesInduction of interleukinBronchoalveolar lavage cellularityHuman leukemia inhibitory factorLung injuryDistress syndromeLavage cellularityPulmonary expressionProtein leakRespiratory effectsOxidant injuryB lymphocytes
1987
Qc-1, a novel Q-region-controlled CTL determinant expressed on B lymphocytes.
Homer RJ, Murphy DB. Qc-1, a novel Q-region-controlled CTL determinant expressed on B lymphocytes. The Journal Of Immunology 1987, 138: 4322-8. PMID: 2438340, DOI: 10.4049/jimmunol.138.12.4322.Peer-Reviewed Original Research