Airway Hyperresponsiveness and Airway Obstruction in Transgenic Mice
Kuhn C, Homer R, Zhu Z, Ward N, Flavell R, Geba G, Elias J. Airway Hyperresponsiveness and Airway Obstruction in Transgenic Mice. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 289-295. PMID: 10696065, DOI: 10.1165/ajrcmb.22.3.3690.Peer-Reviewed Original ResearchConceptsLittermate control miceTransgenic miceAirway obstructionControl miceIL-11Basal airway resistanceIL-6 (-/-) miceSubepithelial airway fibrosisObstructive lung diseasePathophysiology of asthmaAirway wall thicknessAirway fibrosisAirway hyperresponsivenessAirway reactivityMethacholine responsivenessAirway physiologyAirway responsesAirspace enlargementAirway resistanceCaliber changeIL-6Lung diseaseMononuclear cellsPulmonary disordersLuminal diameter