2012
Susceptibility to Progressive Cryptococcus neoformans Pulmonary Infection Is Regulated by Loci on Mouse Chromosomes 1 and 9
Carroll SF, Lafferty EI, Flaczyk A, Fujiwara TM, Homer R, Morgan K, Loredo-Osti JC, Qureshi ST. Susceptibility to Progressive Cryptococcus neoformans Pulmonary Infection Is Regulated by Loci on Mouse Chromosomes 1 and 9. Infection And Immunity 2012, 80: 4167-4176. PMID: 22988020, PMCID: PMC3497416, DOI: 10.1128/iai.00417-12.Peer-Reviewed Original ResearchConceptsC3H/HeN miceCBA/J miceHeN micePulmonary infectionJ miceFungal burdenSusceptible C3H/HeN miceInterleukin-5Cryptococcus neoformans Pulmonary InfectionIL-13 protein expressionHigher pulmonary expressionLung fungal burdenGoblet cell metaplasiaTh2 immune responsePathogenesis of pneumoniaIL-17 proteinCBA/JCryptococcal pneumoniaGreater airwayTissue neutrophiliaCryptococcal infectionCell metaplasiaIntratracheal infectionPulmonary inflammationTissue eosinophilia
1999
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
Zhu Z, Homer R, Wang Z, Chen Q, Geba G, Wang J, Zhang Y, Elias J. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. Journal Of Clinical Investigation 1999, 103: 779-788. PMID: 10079098, PMCID: PMC408149, DOI: 10.1172/jci5909.Peer-Reviewed Original ResearchConceptsMucus cell metaplasiaAirway hyperresponsivenessIL-13Airway fibrosisCell metaplasiaPulmonary expressionCharcot-LeydenInflammatory responseBaseline airway resistanceSubepithelial airway fibrosisTransgene-negative littermatesVivo effector functionNonspecific airway hyperresponsivenessTransgene-positive miceEosinophilic inflammatory responseEpithelial cell hypertrophyGranulocyte-macrophage colony-stimulating factorTransgene-positive animalsColony-stimulating factorClara cell 10Cause inflammationMucus hypersecretionSubepithelial fibrosisAirway resistanceEotaxin production