2006
Role of Early Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling*
Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG. Role of Early Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling*. Journal Of Biological Chemistry 2006, 281: 8161-8168. PMID: 16439363, DOI: 10.1074/jbc.m506770200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar LavageCaspasesCell DeathCollagenDNAEarly Growth Response Protein 1Enzyme InhibitorsFibrosisFlavonoidsImmunoblottingIn Situ Nick-End LabelingInflammationInterleukin-13LungMatrix Metalloproteinase 9MiceMice, Inbred C57BLMice, TransgenicMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Models, BiologicalModels, StatisticalRNARNA, MessengerSTAT6 Transcription FactorTh2 CellsTime FactorsTransforming Growth Factor betaTransforming Growth Factor beta1TransgenesConceptsIL-13Early growth response 1IL-13-induced tissue responsesEgr-1Transgenic IL-13Matrix metalloproteinase-9Wild-type miceResponse 1Th2 inflammationCXC chemokinesMetalloproteinase-9Type miceMetalloproteinase-1Transgenic miceAlveolar remodelingTissue inhibitorInflammationPotent stimulatorImportant stimulatorMiceTissue effectsKey roleTissue responsePathogenesisApoptosis regulator
2001
IL-11: Insights in asthma from overexpression transgenic modeling
Zheng T, Zhu Z, Wang J, Homer R, Elias J. IL-11: Insights in asthma from overexpression transgenic modeling. Journal Of Allergy And Clinical Immunology 2001, 108: 489-496. PMID: 11590369, DOI: 10.1067/mai.2001.118510.Peer-Reviewed Original ResearchConceptsIL-11Potential effector functionsMajor basic proteinMurine findingsAirway obstructionSevere asthmaAsthmatic airwaysSubepithelial fibrosisMononuclear infiltrateTissue inflammationFibroblast supernatantsAlveolar developmentVirus infectionPlatelet reconstitutionEffector functionsNonrespiratory tissuesExaggerated quantitiesTransgenic miceDisease severityVariety of stimuliStructural cellsImportant stimulatorSoluble factorsTransgenic modelingEpithelial cells