2004
Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA. Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation. Science 2004, 304: 1678-1682. PMID: 15192232, DOI: 10.1126/science.1095336.Peer-Reviewed Original ResearchConceptsTh2 inflammationAcidic mammalian chitinaseIL-13-induced responsesPathway activationTh2-dominated disordersMammalian chitinaseAirway hyperresponsivenessAsthma modelT helperHuman asthmaChemokine inductionInterleukin-13Exaggerated quantitiesImportant mediatorEpithelial cellsAsthmaInflammationActivationHyperresponsivenessInfection
2003
Transgenic Modeling of Interleukin-13 in the Lung
Elias JA, Zheng T, Lee CG, Homer RJ, Chen Q, Ma B, Blackburn M, Zhu Z. Transgenic Modeling of Interleukin-13 in the Lung. CHEST Journal 2003, 123: 339s-345s. PMID: 12628968, DOI: 10.1378/chest.123.3_suppl.339s.Peer-Reviewed Original ResearchConceptsChemokine receptor 2Vascular endothelial growth factorIL-13 inducesRegulation of inflammationGrowth factor-β1Endothelial growth factorOverexpression transgenic miceAsthma pathogenesisMurine airwaysKey cytokineInterleukin-13Receptor 2Factor-β1Transgenic miceIL-11Transgenic modelingLungGrowth factorPhenotypic alterationsGenetic targetsAirwayInflammationInterleukinStudy resultsCytokines